TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial

TLR Agonists in Glioma Treatment: Clinical Trial Results

Key Points:

In a phase II clinical trial, TLR agonists poly-ICLC and resiquimod were combined with autologous tumor lysate-pulsed dendritic cell vaccination in patients with malignant gliomas.

The goal was to assess the best combination to boost immune response while ensuring safety.

The combination was safe and improved immune responses, including increased interferon gene expression and changes in immune cell activation.

Patients with higher interferon response gene expression showed prolonged survival and delayed disease progression.

Practical Solutions and Value:

Combining ATL-DC vaccination with poly-ICLC can induce a polarized interferon response in circulating monocytes and CD8+ T cells, potentially serving as an important blood biomarker for immunotherapy.

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