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Tolerance induction through early feeding to prevent food allergy in infants and children with sensitization against food allergens (TIFFANI): rationale, study design, and methods of a randomized controlled trial

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The TIFFANI Study: Tolerance Induction through Early Feeding to Prevent Food Allergy in Infants and Children

The Rationale Behind the Study

Food allergies affect a significant number of individuals and there is currently no cure. The TIFFANI study aims to explore the potential of early feeding to prevent food allergies in infants and children.

The Study Design and Methods

The study is a randomized controlled trial, where participants will be randomly assigned to receive early exposure to potential allergens through food or follow standard feeding practices. The study will include infants and children between the ages of 4-6 months who have been identified as having sensitization to potential food allergens but have not yet developed an allergy.

Expected Outcomes

The primary outcome is to determine if early exposure to potential allergens through food can prevent the development of food allergies. Secondary outcomes include looking at the severity of allergic reactions, quality of life, and healthcare costs associated with food allergies.

Conclusion

The TIFFANI study is an important step towards understanding the role of early feeding in preventing food allergies. The results of this study have the potential to change the way we approach food allergies and could have a significant impact on the lives of millions of people worldwide.

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