VATICAN Trial: Evaluating Antibiotic Treatment for Ventilator-Associated Tracheobronchitis
Background: Ventilator-associated tracheobronchitis is a common condition in intensive care units, and the best treatment strategy is currently unknown. The VATICAN trial aims to compare watchful waiting with routine antibiotic treatment for this condition.
Methods:
The VATICAN trial is a randomized, controlled, open-label, multicenter noninferiority trial. Patients with suspected ventilator-associated tracheobronchitis will be assigned to either a watchful waiting strategy or routine antimicrobial treatment for seven days. The primary outcome will be mechanical ventilation-free days at 28 days, with ventilator-associated pneumonia-free survival as a key secondary outcome.
Conclusion:
The VATICAN trial will adhere to ethical standards and aims to provide results that can immediately impact bedside care and guideline development.
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