Short-term Study Results on Arsenic Trioxide Treatment for High-risk Neuroblastoma in Children
Overview
A clinical study was conducted to assess the effectiveness and safety of arsenic trioxide (ATO) in combination with a modified N7 induction regimen for children with high-risk neuroblastoma (NB).
Key Findings
- 93% of patients achieved objective remission, with a 94% disease control rate.
- Common adverse reactions included myelosuppression (90%), gastrointestinal symptoms (49%), infections (30%), hepatotoxicity (6%), and cardiovascular toxicity (2%).
- No chemotherapy-related deaths were reported.
Practical Solutions and Value
The combination of ATO and N7-modified regimen showed superior efficacy and safety, highlighting its potential for wider clinical application.
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