Assessment of MMP Levels and Clinical Success in Pulpitis and Pulpotomy Treatment
Background
Matrix metalloproteinases (MMPs) are crucial enzymes in dental pulp tissue function. However, their role in primary teeth remains limited. Further studies are needed to understand their contributions to pulpal defense in primary teeth. Additionally, the effectiveness of Biodentine in treating primary teeth requires further exploration.
Aim
The study aims to compare MMP-2, MMP-8, and MMP-9 levels in reversible and irreversible pulpitis. It also seeks to assess the success of Mineral Trioxide Aggregate (MTA) and Biodentine in pulpotomy treatments for primary molars.
Design
63 primary molars were included in a randomized trial, with subgroups based on pulpitis diagnosis. MMP levels were evaluated for all samples, and pulpotomy treatments were performed using MTA and Biodentine in respective subgroups. Clinical and radiographic evaluations were conducted over an 18-month follow-up period.
Results
MMP-2 and MMP-9 levels were significantly elevated in irreversible pulpitis cases, suggesting a potential correlation with pulpal inflammation severity. Clinical success rates of pulpotomies with MTA and Biodentine were similar for reversible pulpitis cases.
Conclusions
The study suggests that MMP-2 and MMP-9 levels can serve as biomarkers for assessing pulpal inflammation in primary teeth. Moreover, Biodentine demonstrates promising clinical success in pulpotomy procedures, supporting its efficacy as an alternative to MTA.
Clinical Trial Registration
The study protocol has been registered with an ID: NCT05145686. Registration Date: 9th November 2021.
PMID:39215293 | PMC:PMC11365239 | DOI:10.1186/s12903-024-04795-5
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