Study Title: Calcium Dibutyryl Adenosine Cyclophosphate Enhances the Effect of Metoprolol in Treating Older Adults With Heart Failure Combined With Arrhythmia
Objective:
To investigate the effectiveness and safety of combining calcium dibutyryl adenosine cyclophosphate (dbcAMP-Ca) with metoprolol in treating older adults with heart failure and arrhythmia.
Methods:
– 102 elderly patients were enrolled and randomly assigned to a control group (n=51) and an experimental group (n=51).
– The control group received metoprolol, while the experimental group received dbcAMP-Ca in addition to metoprolol.
– Both groups were treated for 4 weeks, and various clinical parameters were measured.
Results:
– The experimental group showed a higher rate of effective response to treatment compared to the control group.
– Several cardiac function and hemorheology indexes were improved in the experimental group.
– The experimental group also exhibited better heart rate variability and exercise capacity.
– Levels of myocardial injury and inflammatory markers were more favorable in the experimental group.
– The incidence of adverse reactions was comparable between the two groups.
Conclusion:
The combination of dbcAMP-Ca and metoprolol effectively improved cardiac function, heart rate variability, and exercise tolerance while reducing inflammatory response in elderly patients with heart failure and arrhythmia, with high medication safety.
Practical Solutions and Value:
– The combination medication demonstrated better safety and therapeutic effects compared to metoprolol alone.
– This study highlights the potential benefits of combining dbcAMP-Ca with metoprolol in treating older adults with heart failure and arrhythmia.
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