Clinical trials

Background Helicobacter pylori (H. pylori) infections are common and can lead to serious stomach issues. A big problem is that many treatments are not working anymore because the bacteria have become resistant to clarithromycin, a common antibiotic. To address this, doctors are now recommending a different kind of treatment called concomitant therapy, especially in places […] ➡️➡️➡️

Background Seizures are common in patients with brain tumors, affecting their daily lives and increasing healthcare costs. Levetiracetam is the most frequently prescribed medication to prevent seizures after brain surgery. Typically, patients take it for 2-3 years, but the actual need for such a long duration is unclear. This study aims to compare a shorter […] ➡️➡️➡️

Background Children’s lungs are different from adults’, making them more prone to breathing problems after certain surgeries. This study aimed to create a tool (a nomogram) to help predict these issues in children undergoing thoracic surgery with one-lung ventilation. Methods We studied 361 children who had this type of surgery. They were split into two […] ➡️➡️➡️

Study Overview This study explored how a medication called escitalopram, which is often used to treat depression, affects learning from rewards and punishments. It involved 64 healthy volunteers who took either escitalopram or a placebo for three weeks. Key Findings Participants who took escitalopram showed less learning from punishments compared to those who took the […] ➡️➡️➡️

Abstract The EORTC QLQ-OES18 is a tool used to measure symptoms in patients with advanced esophageal squamous cell carcinoma (ESCC). This study looked closely at how well this tool works in a specific patient group. Methodology Data from a large clinical trial (RATIONALE 302) was analyzed. This trial compared a new treatment called tislelizumab to […] ➡️➡️➡️

Study Overview This study examined how two medications, acarbose and vildagliptin, affect levels of a substance called trimethylamine N-oxide (TMAO) in overweight and obese patients with type 2 diabetes. TMAO is linked to diabetes and its complications. Study Design We conducted a randomized controlled trial with 100 participants who were newly diagnosed with type 2 […] ➡️➡️➡️

Background Every year, 45,000 women globally are diagnosed with vulvar cancer, which often arises from a precancerous stage called vulvar high-grade squamous intraepithelial lesions (vHSIL). This condition is linked to high-risk human papillomavirus (HPV). Over 30% of women experience vHSIL recurrence even after treatment, leading to serious physical and emotional challenges. Our study explores an […] ➡️➡️➡️

Study Overview This study looked at how effective intranasal oxytocin (40 IU) is when used with Alcohol Behavioral Couple Therapy (ABCT) for treating alcohol use disorder (AUD). It compared the effects of oxytocin to a placebo (saline). Trial Details The clinical trial lasted for 12 weeks and was conducted from 2018 to 2024. It was […] ➡️➡️➡️

Study Overview This study examines the effectiveness of red ointment, a common topical treatment in traditional Chinese medicine, for helping wounds heal after surgery for non-puerperal mastitis (NPM). Methods A clinical trial involved 88 patients with NPM. They were randomly placed into two groups. Both groups had surgery to clean their wounds: Treatment Group: Received […] ➡️➡️➡️

Study Overview This study looked at two important ways to measure how well treatments work for patients with systemic lupus erythematosus (SLE). These methods are called BICLA and SRI4. We wanted to see how often these methods agreed or disagreed when looking at patients who received standard care or a placebo in two clinical trials: […] ➡️➡️➡️

Preventing Screen Time Issues in Young Children Screen time for children under three can lead to health and development problems. This study focuses on a program designed to help pediatricians manage screen time during regular check-ups. Study Overview The study is a large trial across Germany. Two-thirds of pediatric practices received special tools to help […] ➡️➡️➡️

Background There is a need for affordable ways to help people with anxiety disorders. DIALOG+ is a proven method designed to improve meetings between patients and healthcare providers in mental health care. While it has shown benefits in various studies, it had not been tested specifically for anxiety disorders until now. Methods We conducted a […] ➡️➡️➡️

Importance of Clinical Trials Effective treatments for visual field defects (VFDs) in stroke patients need to be tested through clinical trials. Objective of the Study This study aimed to assess the safety and effectiveness of a personalized digital therapy that uses visual perceptual learning to treat VFDs after a stroke. Study Overview The trial took […] ➡️➡️➡️

Importance of Self-Collected Cervical Screening Many women in the US who are at risk for cervical cancer are not getting screened. A new at-home self-collection (SC) method for cervical screening has been approved, which can help overcome barriers that prevent women from visiting clinics. Study Overview This study tested a self-collection device designed for home […] ➡️➡️➡️

Background The use of dental implants is growing, but many patients experience inflammation around these implants. This study explored how a special treatment called antibacterial dual-light photodynamic therapy (aPDT) can help reduce this inflammation. Study Overview We included 40 patients who were newly diagnosed with peri-implant disease. They were divided into two groups: one group […] ➡️➡️➡️

Background People with mild intellectual disability (MID) or borderline intellectual functioning (BIF) often face higher risks of developing post-traumatic stress disorder (PTSD). This can lead to various behavioral issues. It’s essential to explore effective therapies like Eye Movement Desensitization and Reprocessing (EMDR) for these individuals. Objective This study aimed to evaluate the safety and effectiveness […] ➡️➡️➡️

Background Research has shown that using beta-blockers in patients with chronic obstructive pulmonary disease (COPD) might lower the chances of worsening their condition. However, there was no definitive clinical trial to confirm this until now. Objective This study aimed to evaluate how effective and cost-efficient it is to add bisoprolol (a type of beta-blocker) to […] ➡️➡️➡️

Understanding COPD and the Role of Albuterol Digihaler Chronic obstructive pulmonary disease (COPD) can worsen unexpectedly, and many patients and caregivers may not notice these changes. Recognizing when COPD is getting worse is crucial for better care. This study focused on using the Albuterol Digihaler to help track and predict these changes. Study Overview In […] ➡️➡️➡️

“`html Effectiveness of Procalcitonin in Antibiotic Treatment for Children Background Procalcitonin is a marker that helps identify bacterial infections quickly, faster than other tests like C-reactive protein. However, it is not commonly used in the National Health Service (NHS). Objective The goal of this study was to see if using a procalcitonin-guided approach could safely […] ➡️➡️➡️

Study Overview This study investigates the effectiveness of teeth whitening methods and the comfort levels of patients using different treatments. It focuses on using violet LED lights with hydrogen peroxide to determine the best way to achieve whiter teeth while minimizing sensitivity. Methods In a single-blind randomized controlled trial, 84 participants were divided into three […] ➡️➡️➡️