Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePhase II trial of nab-paclitaxel plus ramucirumab in combination with nivolumab for unresectable advanced or recurrent gastric cancer after progression on first-line treatment including fluoropyrimidine, platinum, and anti-PD-1/PD-L1 antibody (PADDLE)
Phase II Trial Overview Study Title: PADDLE This trial investigates the combination of nab-paclitaxel, ramucirumab, and nivolumab for patients with advanced gastric cancer (AGC) who have not responded to previous treatments. Background Patients with AGC often have limited survival after initial treatments. New research suggests that continuing immunotherapy after disease progression can be beneficial. The […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseTissue Doppler echocardiography predicts long-term cardiovascular mortality: the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) legacy 20-year follow-up study
Tissue Doppler Echocardiography and Long-Term Cardiovascular Mortality Study Overview This study examines how tissue Doppler echocardiography can predict long-term cardiovascular mortality in hypertensive patients based on data from the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). Key Findings Background: Left ventricular diastolic function, evaluated through tissue Doppler echocardiography, has shown to predict cardiovascular events within 4 years […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of selective caries removal and photobiomodulation on postoperative sensitivity in deep cavities: randomized clinical trial
Effect of Selective Caries Removal and Photobiomodulation on Postoperative Sensitivity Study Overview This clinical trial studied how selective removal of decay in deep cavities affects sensitivity after dental procedures. It involved 33 molars and compared three different treatment methods. Methods The teeth were divided into three groups: Control Group: Selective removal of infected dentine only. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseIntracameral Enoxaparin for Descemet Membrane Endothelial Keratoplasty: A Pilot Safety Study
Intracameral Enoxaparin for Descemet Membrane Endothelial Keratoplasty: A Pilot Safety Study Study Overview The goal of this study was to assess the safety and results of using intracameral enoxaparin during Descemet membrane endothelial keratoplasty (DMEK). Methods The study included two parts: a clinical multicenter retrospective cohort arm (CA) and an ex vivo basic science arm […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePrediction and prevention of fascial dehiscence after laparotomy
Prediction and Prevention of Fascial Dehiscence After Laparotomy Objective The goal of this study was to assess how effective a special suture technique is in preventing fascial dehiscence (a complication where the surgical wound reopens) in patients who have certain risk factors during and after abdominal surgery. Methods This study looked at 112 patients who […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePhenomapping the Response of Patients With Ischemic Cardiomyopathy With Reduced Ejection Fraction to Surgical Revascularization
Phenomapping Patient Responses to CABG in Ischemic Cardiomyopathy Study Overview Coronary artery bypass grafting (CABG) can improve long-term survival for patients with heart failure and blocked arteries. This study explores how different patient characteristics affect the benefits of CABG. Research Methods We analyzed data from the STICHES trial, which compared CABG plus medical treatment to […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Visceral adipose tissue area and proportion provide distinct reflections of cardiometabolic outcomes in weight loss; pooled analysis of MRI-assessed CENTRAL and DIRECT PLUS dietary randomized controlled trials
Study on Visceral Adipose Tissue and Weight Loss Background Visceral adipose tissue (VAT) is a harmful type of body fat that can negatively affect health, while superficial subcutaneous adipose tissue (SAT) has little to no negative impact. This study looks at how VAT area and its proportion of total abdominal fat during weight loss can […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImplementation of a rapid host-protein diagnostic test for distinguishing bacterial and viral infections in adults presenting to urgent care centers: a pragmatic cohort study
Implementation of a Rapid Diagnostic Test for Infections Study Overview This study evaluated a new blood test, MeMed BV® (MMBV), which can tell if an infection is bacterial or viral. The test was used in ten urgent care centers (UCCs) from April 2022 to March 2023. The main goal was to see how the test […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseVisual, clinical and quality of life outcomes of a new multifocal IOL with optimized diffractive grating: a non-randomized clinical trial
Visual, Clinical, and Quality of Life Outcomes of a New Multifocal IOL Study Overview This study focuses on the BIOS Trifocal intraocular lens (IOL), designed to help patients see clearly at various distances without needing glasses. The lens aims to minimize issues like halos and glare, which can occur with other multifocal lenses. Key Features […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseShift from chronic to episodic migraine frequency in a long-term phase 3 study of galcanezumab
Shift from Chronic to Episodic Migraine Frequency in a Long-Term Phase 3 Study of Galcanezumab Background Chronic migraine (CM) is a severe condition where patients experience 15 or more headache days per month, with at least 8 being migraine-type headaches. Galcanezumab is a medication designed to prevent migraines. A key goal in treating CM is […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of Cognitive Behavioral Therapy Provided Through a Web Application for Subthreshold Depression, Subthreshold Insomnia, and Subthreshold Panic: Open-Labeled 6-Arm Randomized Clinical Trial Pilot Study
Effectiveness of Online Cognitive Behavioral Therapy for Mild Depression, Insomnia, and Panic: A Clinical Trial Study Background Many people experience symptoms of depression, insomnia, or panic that are not severe enough to be diagnosed as a mental health disorder. However, these symptoms can still make daily life challenging and lower quality of life. There is […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Unified Protocol vs Mentalization-Based Therapy for Adolescents With Borderline Personality Disorder: A Randomized Controlled Trial
Unified Protocol vs Mentalization-Based Therapy for Adolescents With Borderline Personality Disorder Study Overview This study compares two treatments for adolescents with borderline personality disorder (BPD): Mentalization-Based Therapy for Adolescents (MBT-A) and Unified Protocol for Adolescents (UP-A). It involved 91 Iranian adolescents, mostly female, to see which treatment better reduces BPD symptoms. Methodology Participants were randomly […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePost-Acute Care Interventions in Patients Hospitalized Due to COPD Exacerbation Before and After Implementation of an Integrated Care Program
Post-Acute Care Interventions for COPD Patients Study Overview This study focused on improving care for patients hospitalized due to COPD exacerbations in Switzerland. While inpatient care is good, there was a need for better post-acute care. An integrated care program was started at University Hospital Zurich to address this issue. Research Goals The goal was […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseRationale and design of a multicentre randomised controlled trial on circulating tumour DNA-guided neoadjuvant treatment strategy for locally advanced rectal cancer (CINTS-R)
Overview of the CINTS-R Trial Background Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal cancer (LARC). New methods like total neoadjuvant therapy (TNT) and immunotherapy are promising. We need better ways to select patients for these treatments. Our previous research shows that circulating tumour DNA (ctDNA) can help predict treatment outcomes and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Topical intranasal anesthesia impairs trigeminal function and airflow perception
Topical Intranasal Anesthesia and Its Effects Background Topical intranasal anesthesia may affect how we perceive airflow in our noses. This could explain chronic nasal obstruction (CNO) in patients who do not have visible issues like deformities or inflammation. Our goal is to understand how this anesthesia impacts sensitivity in the nose and the feeling of […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA Prospective, Active-controlled, Randomized, Double-blind, Multicenter, Phase III Study to Compare the Safety and Efficacy of Biosimilar Denosumab vs Reference Denosumab in the Treatment of Postmenopausal Osteoporosis
A Study on Biosimilar Denosumab for Postmenopausal Osteoporosis Objective This study aimed to compare the safety and effectiveness of a biosimilar version of denosumab with the original product, Prolia, in Indian women with postmenopausal osteoporosis. Denosumab helps regulate bone turnover by decreasing bone loss. Methods This was a phase III, double-blind study involving postmenopausal women […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparative efficacy of lumbar and pelvic support on pain, disability, and motor control in women with postpartum pelvic girdle pain: a three-armed randomized controlled trial
Comparative Efficacy of Lumbar and Pelvic Support for Postpartum Pain Study Overview This study examined how lumbar and pelvic supports help women with postpartum pelvic girdle pain (PPGP), a common issue after pregnancy. The goal was to see how these supports affect pain, disability, and movement control. Methodology 84 women diagnosed with pregnancy-related PPGP took […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The effect of local anaesthetic agents on opioid use and recovery in patients undergoing open heart surgery: a randomized controlled study
The Effect of Local Anaesthetic Agents on Opioid Use and Recovery in Patients Undergoing Open Heart Surgery BMC Cardiovasc Disord. 2025 Feb 1;25(1):72. Background After open heart surgery, patients often suffer from significant pain at the incision site and around chest tubes, which can slow recovery. This study aimed to see how local anaesthetic applied […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Annual versus less frequent mammographic surveillance in people with breast cancer aged 50 years and older in the UK (Mammo-50): a multicentre, randomised, phase 3, non-inferiority trial
Annual versus Less Frequent Mammographic Surveillance in Older Women with Breast Cancer Study Overview This study, known as Mammo-50, examined whether having mammograms less often than once a year is just as effective for breast cancer survival in women aged 50 and older. Key Methods The trial involved 5,235 women across 114 hospitals in the […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Can the combination of citicoline and vitamin B12 be beneficial in the healing of corneal nerves after corneal cross-linking?
Can Citicoline and Vitamin B12 Help Heal Corneal Nerves After Cross-Linking? Study Overview This study looked at how topical citicoline, vitamin B12, and hyaluronic acid (OMK2 eye drops) affect the healing of corneal nerves after corneal cross-linking (CXL) in patients with keratoconus (KC). Study Details A total of 44 eyes from 22 patients with KC […] ➡️➡️➡️