Community Versus Facility-Based Services for Hepatitis C Screening in Cambodia
Background: Hepatitis C is a major health issue in Cambodia, especially for those over 45 years old, with a prevalence of 5%. Improving access to screening and treatment is essential for eliminating hepatitis C.
Objective:
This study will compare the effectiveness of community-based screening versus facility-based screening for hepatitis C antibody testing in people over 40 years old in Cambodia.
Methods:
The CAM-C study uses a cluster-randomized controlled trial design in two Cambodian provinces. It targets individuals over 40 years old due to their higher risk for hepatitis complications. The study includes:
- Facility-based testing with referrals
- Community-based testing with home assessments
We aim to screen 6,000 individuals to significantly increase testing uptake while ensuring thorough management for positive cases, including potential antiviral treatments.
Results:
The study protocol was approved in 2019, and participant recruitment will conclude by mid-2024, with analysis beginning in May 2024.
Conclusions:
This mixed methods study combines a cluster-randomized controlled trial with cost-effectiveness analysis and qualitative research. It will provide valuable insights for the Ministry of Health to enhance hepatitis C screening strategies and work towards elimination.
Trial Registration: ClinicalTrials.gov NCT03992313; https://clinicaltrials.gov/study/NCT03992313.
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