Itinai.com biomedical laboratory close up still scene close u fd75bc8f 7c64 495f bcb3 944db9509d75 2
Itinai.com biomedical laboratory close up still scene close u fd75bc8f 7c64 495f bcb3 944db9509d75 2

Detection of hypovolemia by non-invasive hemodynamic monitoring during major surgery using Ringers solution, 5% albumin, or 20% albumin as infusion fluid: a post-hoc analysis of a randomized clinical trial

Background

Fluid loading is a common treatment for major bleeding, but it can sometimes lead to too much fluid in the body. We looked at different ways to replace fluids during major surgeries and how well certain tests can identify low blood volume.

Methods

In our study, we randomly assigned 42 patients to receive one of three types of fluid treatments: 5% albumin, 20% albumin, or Ringer’s solution. We measured various factors like blood flow and pressure to see how effective each treatment was.

Results

Using only Ringer’s solution led to slight low blood volume and increased heart rate. The 5% and 20% albumin treatments were better at filling the blood vessels. The study found that:

  • 5% albumin was good at detecting low blood volume over 500 mL.
  • PVI (plethysmographic variation index) worked well with Ringer’s solution.
  • Cardiac output (CO) was effective when using 20% albumin.

Conclusions

Different fluids affect how well we can detect low blood volume. Monitoring blood volume using non-invasive methods is still challenging and often not very accurate.

Opportunities for Clinics and Patients

Based on our findings, clinics can:

  • Set clear goals for detecting low blood volume during surgeries.
  • Use tailored AI tools to improve monitoring and treatment.
  • Start small pilot projects to track the effectiveness of these tools.

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