Effect of Endothelin-1 on Blood Pressure Response to Hypoxia and Hyperoxia in Young Men
Physiological Reports, 2024 Sep;12(17):e70004
Endothelin-1 (ET-1) and its receptors have been linked to increased sensitivity to hypoxic stress and the development of hypertension. This study aimed to investigate the effect of ET receptor antagonism on blood pressure (BP) response to chemoreflex stress.
Twenty-four young men completed two study visits, one with a control and the other with bosentan. BP was assessed under normoxia, hypoxia, and hyperoxia conditions. Bosentan increased plasma ET-1, supporting receptor blockade. Resting diastolic and mean BP were reduced following bosentan compared to control, with no change in systolic BP. The BP response to both acute hypoxia and hyperoxia was attenuated following bosentan, indicating that ET receptor inhibition can affect BP during chemoreflex stress in healthy young men. These findings suggest a role for ET-1 in controlling resting BP, possibly through a chemoreceptor-mediated mechanism.
PMID: 39218615 | PMC: PMC11366443 | DOI: 10.14814/phy2.70004
Clinical Trials and AI-Driven Solutions for Healthcare
Clinical trials play a vital role in developing safe and effective treatments, and it’s essential to integrate their benefits into everyday medical practice. Our AI-driven platform, DocSym, consolidates ICD-11 standards, clinical protocols, and research into a single, easily accessible knowledge base for clinicians.
In today’s healthcare environment, optimizing operations is crucial. Our mobile apps support scheduling, monitoring treatments, and telemedicine, making it easier to manage patient care and expand services digitally.
By leveraging AI, clinics can streamline workflows, improve patient outcomes, and reduce paper-based routines. Learn more about how we can help at aidevmd.com.
