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Effect of timing of antibiotic use on premature rupture of membranes and its impact on reproductive tract infection and fetal membrane cell scorching indicators

Study Overview

This study looked at how the timing of antibiotic use affects infections and cell damage in pregnant women with premature rupture of membranes (PROM).

Key Findings

  • Participants: 107 pregnant women with PROM were divided into two groups.
  • Intervention Group: 54 women received ampicillin within 24 hours of PROM.
  • Control Group: 53 women received ampicillin 24-48 hours after PROM.

Results

  • The intervention group had significantly better outcomes for both mothers and babies (p<0.05).
  • Infections like Chlamydia trachomatis and Mycoplasma solium were lower in the intervention group (p<0.05).
  • Indicators of cell damage in placental tissues were also lower in the intervention group (p<0.05).

Conclusion

Giving antibiotics within 12 hours of PROM can reduce infections, lower cell damage, and improve outcomes for mothers and babies. This supports the need for early antibiotic treatment in PROM cases.

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