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Efficacy of high-dose vs. low-dose vitamin D3 supplementation in children with chronic tic disorders: a randomized controlled trial

Vitamin D₃ for Tic Disorders in Children

Background

Vitamin D₃ might help reduce tic symptoms in children with chronic tic disorders (CTDs). This study looked at how different doses of vitamin D₃ affect tic severity and vitamin D levels in kids diagnosed with CTDs.

Study Overview

In the study, 83 children aged 4 to 15 were randomly assigned to receive either:

  • High-dose vitamin D₃: 5,000 IU/day
  • Low-dose vitamin D₃: 1,000 IU/day

The treatment lasted for three months. The main focus was on reducing tic severity, measured using a standard scale (YGTSS). Researchers also checked vitamin D and calcium levels before and after treatment.

Results

Both groups saw improvements in tic severity and increases in vitamin D levels:

  • Both doses were effective (𝑝 < 0.05).
  • The high-dose group had better results in reducing tics compared to the low-dose group (𝑝 < 0.05).
  • No significant differences in calcium levels were found (𝑝 > 0.05).
  • A strong link was found between higher vitamin D levels and reduced tic severity (𝑡 = -2.816, 𝑝 < 0.05).

Conclusion

High-dose vitamin D₃ is more effective than low-dose in reducing tic severity and increasing vitamin D levels in children with CTDs. This suggests that it could be a helpful addition to treatment for managing CTDs.

Practical Applications for Clinics and Patients

Based on the study results, here are some actionable items:

  • Define Clear Goals: Focus on reducing tic severity and increasing vitamin D levels as measurable outcomes.
  • Implement Pilot Projects: Start small with high-dose vitamin D₃ in practice settings and track results.
  • Select Suitable AI Tools: Use AI solutions that align with clinical needs to monitor patient progress and treatment efficacy.

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