Efficacy of Highly Bioavailable Oral Curcumin in Asymptomatic or Mild COVID-19 Patients: A Double-Blind, Randomized, Placebo-Controlled Trial
Introduction
Curcumin, known for its anti-inflammatory properties, has the potential to inhibit disease progression in COVID-19 patients. A highly absorbable form of curcumin, curcuRouge® (cR), was developed, and its effect on asymptomatic or mildly symptomatic COVID-19 patients was evaluated.
Methods
The study involved a 7-day oral intake of cR (360 mg twice daily) for patients within 5 days of COVID-19 diagnosis, with random assignment to a placebo or cR group in a double-blind manner.
Results
The cR group showed a lower rate of primary endpoint events (body temperature ≥ 37.5 °C and saturation of percutaneous oxygen < 96%) compared to the placebo group. Patients receiving cR also tended to take fewer antipyretic medications. Additionally, among patients with a normal range of body temperature at baseline, the cR group showed a significantly lower body temperature change rate compared to the placebo group.
Conclusion
The findings support the anti-inflammatory effects of cR in asymptomatic or mildly symptomatic patients with COVID-19, as evidenced by the relative suppression of event rates and antipyretic medications taken, as well as the significant decrease in subclinical body temperature.
Trial Registration
Japan Registry of Clinical Trials (CRB5200002)
Practical Solutions and Value
Clinical trials play a crucial role in developing safe and effective treatments, and it’s important to translate their benefits into everyday medical practice. Our AI-driven platform, DocSym, consolidates ICD-11 standards, clinical protocols, and research into a single, easily accessible knowledge base for clinicians. Additionally, our mobile apps support scheduling, monitoring treatments, and telemedicine, streamlining operations and making it easier to manage patient care and expand services digitally. By leveraging AI, clinics can enhance workflows, improve patient outcomes, and reduce paper routines.
Learn more about how we can help at aidevmd.com.
