General health and social outcomes 50 years after exposure to antenatal betamethasone: follow-up of a randomised controlled trial

Long-Term Effects of Antenatal Betamethasone: Key Findings

Study Overview

This study looked at the health and social outcomes of individuals who were exposed to antenatal betamethasone 50 years ago. Antenatal corticosteroids are given to pregnant women at risk of preterm birth to help reduce complications for newborns.

Methodology

We followed 424 adults whose mothers participated in a major clinical trial. Mothers received either betamethasone or a placebo, and we evaluated various health and social outcomes through questionnaires and administrative data.

Main Findings

Overall, there were no significant differences in mental health, general health, or social outcomes between those who received betamethasone and those who received a placebo. However, individuals exposed to betamethasone had a higher risk of osteoporotic fractures in adulthood.

Conclusion

The study suggests that antenatal corticosteroids do not have significant long-term effects on general health and social outcomes up to the age of 50.

Practical Solutions and Value

Clinical trials are essential for developing safe treatments. To enhance the application of these findings in everyday medical practice, we recommend:

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