Health-related Quality of Life in Patients with Metastatic Basal Cell Carcinoma Treated with Cemiplimab: Analysis of a Phase 2 Trial
Key Findings:
A phase 2 study of cemiplimab showed a 24.1% objective response rate in patients with metastatic basal cell carcinoma who were not suitable for continued hedgehog inhibitor therapy. The study focused on assessing the health-related quality of life (QoL) for this patient population.
Study Method:
Adult patients with metastatic basal cell carcinoma received intravenous cemiplimab treatment. Their QoL was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life-Core 30 (QLQ-C30) and Skindex-16 questionnaires at baseline and throughout the treatment cycles.
Results:
Patients reported low symptom burden and moderate-to-high functioning at baseline. The analysis revealed that most patients experienced maintenance or improvement in global health status/QoL, functioning, and symptom scales throughout the treatment cycles. The majority of patients reported clinically meaningful improvement or maintenance in various aspects of QoL, including emotional, symptom, and functional subscales.
Conclusion:
The majority of patients treated with cemiplimab reported improvement or maintenance in global health status/QoL and functioning while maintaining a low symptom burden.
Source: Cancer Med. 2024 Jul;13(14):e7360. doi: 10.1002/cam4.7360.
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