Intraindividual Comparison of MRI Contrast Agents for Liver Lesions
Study Overview
This study compared two MRI contrast agents, gadobenate and gadoxetate, in assessing liver lesions in the same individuals.
Methodology
A total of 140 adults participated, undergoing two MRI scans within 7-14 days. One scan used gadobenate (0.05 mmol/kg) and the other used gadoxetate (0.025 mmol/kg). Both scans included various imaging sequences, and three independent experts evaluated the images to determine the nature of the lesions (benign or malignant).
Results
Out of 208 confirmed liver lesions, gadobenate showed better performance:
- Sensitivity and Specificity: Gadobenate ranged from 91.6% to 99.1% sensitivity and 87.5% to 90.5% specificity. Gadoxetate ranged from 86.0% to 91.6% sensitivity and 79.7% to 83.6% specificity.
- Higher Diagnostic Accuracy: Gadobenate provided greater accuracy and confidence in lesion diagnosis for two out of three reviewers.
- Better Agreement: The agreement among readers was higher for gadobenate compared to gadoxetate.
Conclusion
Gadobenate outperformed gadoxetate in differentiating between malignant and benign liver lesions. Further studies are needed for a broader assessment of various liver lesions.
Practical Implications
Using gadobenate may enhance decision-making in patient management, leading to improved outcomes.
Key Takeaways
- Gadobenate provides better diagnostic performance for liver lesions.
- Reader confidence in diagnosing lesions is higher with gadobenate.
- Superior imaging during the dynamic phase is critical for accurate diagnosis.
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