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Molecular Landscape and Therapeutic Strategies against Colorectal Cancer

Molecular Landscape and Therapeutic Strategies against Colorectal Cancer

Molecular Landscape and Therapeutic Strategies against Colorectal Cancer

Practical Solutions and Value

Colorectal cancer (CRC) is the second leading cause of cancer deaths worldwide.
Incidence of young-onset CRC (diagnosis before age 50) is increasing.
Improved outcomes for CRC patients due to comprehensive molecular characterization of tumors and novel therapeutic strategies.
Advances in genomic and transcriptomic analyses have identified distinct tumor subtypes with unique biological characteristics and therapeutic vulnerabilities.
Targeted therapies and immunotherapy are now incorporated into CRC treatment.
Discussion of the molecular landscape and key oncogenes/tumor suppressors contributing to CRC tumorigenesis, metastasis, and therapeutic resistance.
Personalized therapeutic strategies for subsets of CRC patients.
Overview of evolving novel treatments being evaluated in clinical trials.

Full research Molecular Landscape and Therapeutic Strategies against Colorectal Cancer: https://pubmed.ncbi.nlm.nih.gov/38672633/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1B1L42DK3a-JWCV4P_PtHHBmWjwBLFNcDXsYJkbqjQD0Ca7UQh&fc=None&ff=20240427133354&v=2.18.0.post9+e462414

2024-04-27

Clinical trials

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Clinical Research

2025-02-12

Clinical trials

A model based cost-utility analysis of Embedding referral to structured self-management education into standard practice (Embedding) compared to usual care for people with type 2 diabetes diagnosis in the last 12 months in England

Cost-Utility Analysis of Self-Management Education for Type 2 Diabetes Study Overview This study evaluates the cost-effectiveness of a program that helps people with type 2 diabetes (T2DM) access structured self-management…
2024-04-26

Clinical trials

Carbohydrate Antigen 125 (CA 125): A Novel Biomarker in Acute Heart Failure

“`html Carbohydrate Antigen 125 (CA 125): A Novel Biomarker in Acute Heart Failure Practical Solutions and Value Heart failure is a major global health issue with high hospitalization rates and…
2024-12-07

Clinical trials

Effect of Implicit Learning Methods With the External Focus of Attention on Bowling Skills in Children With Autism Spectrum Disorder: A Randomized Control Trial Study

Study on Bowling Skills in Children with Autism Purpose The study aimed to compare two learning methods to improve bowling skills in children with autism spectrum disorder (ASD). Method Twenty…
2024-10-20

Clinical trials

Resting state network changes induced by experimental inaudible infrasound exposure and associations with self-reported noise sensitivity and annoyance

Study Overview This study investigates the impact of inaudible infrasound exposure on brain function and behavior, focusing on changes in brain connectivity. Key Findings 38 participants were exposed to inaudible…
2024-09-24

Clinical trials

Voice-Activated Cognitive Behavioral Therapy for Insomnia: A Randomized Clinical Trial

Voice-Activated Cognitive Behavioral Therapy for Insomnia: A Randomized Clinical Trial Practical Solutions and Value Highlights: Insomnia Impact: Insomnia affects 30-50% of US breast cancer survivors. Objective: To test a voice-activated…
2024-07-17

Clinical trials

Pneumatic retinopexy for primary rhegmatogenous retinal detachment: from a clinical trial to the real-life experience

Pneumatic Retinopexy for Primary Rhegmatogenous Retinal Detachment: Real-World Outcomes Key Findings: 84.3% of patients achieved primary anatomic reattachment 100% of patients achieved final anatomical reattachment after pars plana vitrectomy Best…
2024-04-19

Innovation

Unlocking the Recall Power of Large Language Models: Insights from Needle-in-a-Haystack Testing

“The Rise of Large Language Models in AI Solutions” Large Language Models (LLMs) are transforming Natural Language Processing (NLP) and bringing significant advancements in text generation and machine translation. They…
2024-04-17

Innovation

The Role and Impact of the Chief AI Officer (CAIO) in Modern Business

The Chief AI Officer (CAIO) plays a crucial role in integrating AI technologies into an organization’s operations and aligning them with business objectives and ethical considerations. Unique Contributions and Responsibilities…
2025-02-02

Clinical trials

The effect of local anaesthetic agents on opioid use and recovery in patients undergoing open heart surgery: a randomized controlled study

The Effect of Local Anaesthetic Agents on Opioid Use and Recovery in Patients Undergoing Open Heart Surgery BMC Cardiovasc Disord. 2025 Feb 1;25(1):72. Background After open heart surgery, patients often…
2025-04-21

Clinical trials

The Organic Halo Effect: Perceived Caloric Disparities in High- and Low-Calorie Foods and the Role of Nutrition Label Reading Frequency

Understanding the Organic Halo Effect This study looks at how organic food labels affect people’s views on calorie content and how often they should eat different types of food. It…
2025-02-02

Clinical trials

Comparative efficacy of lumbar and pelvic support on pain, disability, and motor control in women with postpartum pelvic girdle pain: a three-armed randomized controlled trial

Comparative Efficacy of Lumbar and Pelvic Support for Postpartum Pain Study Overview This study examined how lumbar and pelvic supports help women with postpartum pelvic girdle pain (PPGP), a common…
2025-05-22

Clinical trials

Comparison of Therapeutic Outcomes Between Concomitant Therapy and Tailored Therapy for Helicobacter pylori: A Multicenter, Prospective, and Randomized Study

Background Helicobacter pylori (H. pylori) infections are common and can lead to serious stomach issues. A big problem is that many treatments are not working anymore because the bacteria have…
2024-11-17

Clinical trials

Multicentre randomised controlled trial comparing Bankart repair with remplissage and Latarjet procedure in shoulder instability with subcritical bone loss (STABLE): study protocol

Multicentre Randomised Controlled Trial on Shoulder Instability (STABLE): Study Overview Introduction Recurrent shoulder dislocations can damage the labrum and lead to bone loss in the shoulder. There are two main…
2024-12-10

Clinical trials

Effects of Marrubium vulgare Extract on Hormonal Parameters and Clinical Findings in Polycystic Ovarian Syndrome: A Randomized, Placebo-Controlled, Triple-Blind Clinical Trial

Effects of Marrubium vulgare Extract on Hormonal Parameters and Clinical Findings in Polycystic Ovarian Syndrome Introduction Polycystic ovary syndrome (PCOS) is a common hormonal disorder in women of reproductive age.…
2025-04-15

Clinical trials

Updated progression-free survival and final overall survival with maintenance olaparib plus bevacizumab according to clinical risk in patients with newly diagnosed advanced ovarian cancer in the phase III PAOLA-1/ENGOT-ov25 trial

Study Overview The PAOLA-1/ENGOT-ov25 trial studied how well a treatment combining olaparib and bevacizumab works for patients with advanced ovarian cancer that has certain genetic characteristics. Key Findings Patients who…