N-acetylcysteine Supplementation for PCOS
Study Overview
Polycystic ovary syndrome (PCOS) affects 6-20% of women globally. Many women with PCOS experience insulin resistance and high insulin levels, which worsen oxidative stress and contribute to the condition. N-acetylcysteine (NAC) is an antioxidant that may help treat PCOS. This study looked at how NAC affects metabolic health in PCOS mice and its effectiveness in helping women with PCOS ovulate.
Research Methods
Researchers used female mice to create a PCOS model and divided them into groups receiving either NAC, metformin, or a control substance for 12 days. They monitored the mice’s reproductive cycles and measured hormone levels, metabolic health, and oxidative stress. A clinical trial with 230 women with PCOS was also conducted, comparing those taking NAC to a control group during ovulation induction treatments.
Key Findings
- NAC improved reproductive cycles and ovarian health in mice, similar to metformin.
- NAC reduced harmful oxidative stress in oocytes and improved insulin sensitivity.
- In women, those taking NAC needed less medication for ovulation induction and had higher pregnancy rates compared to the control group.
Conclusion
NAC supplementation showed promising results in improving metabolic health in PCOS mice and enhancing ovulation induction in women with PCOS. This suggests that NAC could be a beneficial addition to treatments for women with PCOS.
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