Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis
Study Overview
This study investigated how a medication called semaglutide can help people with obesity and knee osteoarthritis. Losing weight can reduce knee pain, but the effects of semaglutide on knee osteoarthritis have not been thoroughly explored.
Methodology
The trial was conducted over 68 weeks and involved 407 participants across 61 sites in 11 countries. Participants had a body mass index (BMI) of 30 or greater and moderate knee osteoarthritis pain. They were randomly assigned to receive either semaglutide (2.4 mg) or a placebo, alongside advice on diet and exercise.
Results
- Weight Loss: Participants taking semaglutide lost an average of 13.7% of their body weight compared to 3.2% in the placebo group.
- Pain Reduction: The semaglutide group reported a significant drop in pain measured by the WOMAC pain score, with a decrease of 41.7 points compared to 27.5 points for placebo.
- Improved Function: Those taking semaglutide also showed better physical function, improving their SF-36 score by 12 points versus 6.5 points for the placebo group.
- Safety: Serious side effects were similar in both groups, but 6.7% in the semaglutide group discontinued due to gastrointestinal issues, compared to 3.0% in the placebo group.
Conclusion
In conclusion, semaglutide significantly helped reduce both body weight and knee pain in people with obesity and osteoarthritis compared to a placebo.
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