Randomised controlled trial of population screening for atrial fibrillation in people aged 70 years and over to reduce stroke: protocol for the SAFER trial

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Benefits of Population Screening for Atrial Fibrillation in Reducing Stroke Risk

Atrial fibrillation (AF) is a common heart condition that can lead to serious complications such as stroke. The SAFER trial aims to evaluate the benefits of early detection and treatment of AF in reducing the risk of stroke.

Early Detection and Treatment

Population screening can identify individuals with AF who may not have symptoms, allowing for early treatment to reduce the risk of stroke.

Better Management and Cost Savings

Screening can lead to better management of AF, potential cost savings, and improved quality of life for individuals with the condition.

Challenges and Considerations in Implementing Population Screening for Atrial Fibrillation

Implementing population screening for AF presents challenges such as identifying the target population, availability of resources, ethical considerations, and ensuring appropriate follow-up care.

Identifying the Target Population

Determining the appropriate age cut-off and identifying individuals at higher risk of AF and stroke are important considerations.

Resource Availability and Ethical Considerations

Challenges include the availability of resources, ethical concerns about overdiagnosis and privacy, and ensuring proper follow-up care for individuals diagnosed with AF.

Examining the Protocol and Design of the SAFER Trial for Population Screening of Atrial Fibrillation in Older Adults

The SAFER trial aims to determine whether population screening for AF in individuals aged 70 years and over can reduce the incidence of stroke.

Study Protocol and Design

The trial involves a two-arm randomised controlled design, with one group receiving population screening for AF and the other receiving usual care. The study aims to recruit 50,000 participants and assess the cost-effectiveness of population screening for AF in this age group.

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