Conditions: Solid Tumor, Adult; BRCA1 Mutation; BRCA2 Mutation; Ovarian Cancer; Breast Cancer; Prostate Cancer
Interventions: Drug: ACE-86225106 tablet
Sponsors: Acerand Therapeutics (Shanghai) Limited
Recruiting
Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors
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Clinical Research
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Improving and preserving cardiorespiratory fitness, muscle strength and adiposity through a complex lifestyle intervention in community-dwelling older adults with elevated cardiometabolic risk: study protocol for the RESTART randomised controlled trial
Introduction As people age, they face more health issues related to heart and metabolism, which can increase healthcare costs. To help older adults maintain their physical health, the RESTART trial…
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Diagnostic Positron Emission Tomography Imaging with Zirconium-89 Desferrioxamine B Squaramide: From Bench to Bedside
“`html Diagnostic Positron Emission Tomography Imaging with Zirconium-89 Desferrioxamine B Squaramide: From Bench to Bedside Overview Molecular imaging with radiolabeled antibodies and Positron Emission Tomography (PET) can provide valuable information…
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Meet Briefer: An AI-Powered Startup with Jupyter Notebook like Platform that Helps Data Scientists Create Analyses, Visualizations, and Data Apps
Subject: Revolutionizing Data Analysis with AI: Meet Briefer The data analysis industry is undergoing rapid transformation due to advancements in technology, particularly with the influence of Artificial Intelligence (AI). This…
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The effects of remimazolam in combination with estazolam on postoperative hemodynamics and pain intensity in patients undergoing laparoscopic gastrointestinal surgery
Study Title The effects of combining remimazolam with estazolam on postoperative hemodynamics and pain intensity in patients undergoing laparoscopic gastrointestinal surgery Published in BMC Surgery, August 24, 2024 PMID: 39182049…
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Probiotic Limosilactobacillus reuteri Enhances Non-Surgical Periodontal Therapy Outcomes in Stage III-IV Periodontitis
Understanding the Trial Results The study looked at how a probiotic called Limosilactobacillus reuteri, when combined with non-surgical periodontal therapy, affects patients with stage III-IV periodontitis. Here’s what they found:…
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Prognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease
Background Recent studies show that blood tests can help diagnose and predict the progression of Alzheimer’s disease (AD), especially in its early stages. This research aimed to explore how these…
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Atorvastatin Safety and Tolerability in Japanese Children with Acute Kawasaki Disease and Coronary Aneurysms
Findings from the Atorvastatin Trial for Kawasaki Disease What Worked? The trial showed that atorvastatin is safe for Japanese children with acute Kawasaki disease (KD) and coronary artery aneurysms (CAAs).…
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Surgical advantage of modified labial salivary gland biopsy using chalazion forceps: a prospective randomized controlled study
Surgical Advantage of Modified Labial Salivary Gland Biopsy Using Chalazion Forceps: A Prospective Randomized Controlled Study Key Findings: Modified labial salivary gland biopsy (LSGB) using chalazion forceps showed significant advantages…
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A low molecular weight dextran sulphate, ILB, for the treatment of amyotrophic lateral sclerosis (ALS): An open-label, single-arm, single-centre, phase II trial
Study Title: A low molecular weight dextran sulphate, ILB, for the treatment of amyotrophic lateral sclerosis (ALS): An open-label, single-arm, single-centre, phase II trial Summary Amyotrophic lateral sclerosis (ALS) is…
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Constipation Widespread and Comparison of Polyethylene Glycol with Lactulose Efficacy in Treatment of Patients with Constipation
Constipation in Children with Cerebral Palsy: A Study on Treatment Options Introduction Constipation is a common issue in children with cerebral palsy (CP), affecting 26% to 74% of them. This…
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Improving Epilepsy Care: Benefits of Internet Hospital Follow-Up for Patient Quality of Life
Understanding the Benefits of Internet Hospital Follow-Up for Epilepsy Patients What Worked? Patients receiving follow-up care through Internet hospitals (IHs) reported a better quality of life compared to those who…
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Low-added sugar dietary intervention study to mitigate glucose intolerance and improve body composition in adults with cystic fibrosis: a protocol of a double-blind, randomised study
Low-Added Sugar Dietary Intervention Study for Adults with Cystic Fibrosis Introduction Adults with cystic fibrosis (CF) are at a higher risk of developing CF-related diabetes (CFRD), which can lead to…
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Effects of White Noise Intervention on Sleep Quality and Immunological Indicators of Patients with Breast Cancer Undergoing Neoadjuvant Chemotherapy
Effects of White Noise Intervention on Sleep Quality and Immunological Indicators in Breast Cancer Patients Objective The study aimed to assess how white noise affects sleep quality and immune responses…
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Patient-reported outcomes of rezvilutamide versus bicalutamide in combination with androgen deprivation therapy in high-volume metastatic hormone-sensitive prostate cancer patients (CHART): a randomized, phase 3 study
Study on Rezvilutamide vs. Bicalutamide for Prostate Cancer Overview The CHART trial (NCT03520478) was a phase 3 study comparing rezvilutamide (REZ) with bicalutamide (BIC) in patients with high-volume metastatic hormone-sensitive…
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Cost-effectiveness of C-reactive protein point of care testing for safely reducing antibiotic consumption for acute exacerbations of chronic obstructive pulmonary disease as part of the multicentre, parallel-arm, open, individually randomised, controlled PACE trial
Cost-Effectiveness of C-Reactive Protein Testing for Antibiotic Use in COPD Study Overview This study evaluated the use of C-reactive protein point-of-care testing (CRP-POCT) to help reduce unnecessary antibiotic prescriptions in…
