Study Overview
Title: Hybrid Trial for Cervical Cancer Prevention in Uganda
Published: PLoS One, January 24, 2025
Introduction
Cervical cancer (CC) is a major health issue in Uganda, being the top cause of cancer deaths among women. Unfortunately, many women do not get screened for CC. A promising solution is to train women who have recently been screened to advocate for screening within their social circles.
Methods
This study uses a structured approach called the EPIS framework. We are conducting a randomized controlled trial (RCT) named Game Changers for Cervical Cancer Prevention (GC-CCP). The goal is to:
- Increase CC screening rates through peer-led advocacy.
- Implement and sustain this program in various clinic settings.
In the Preparation phase, we will prepare four clinics by identifying barriers to CC screening through interviews and focus groups. In the Implementation phase, the GC-CCP program will run for 36 months, starting with a group of women who have been screened. They will receive training and support to encourage their social networks to get screened. Assessments will occur at the start and at 6 and 12 months.
In the Sustainability phase, clinic staff will take over the program to ensure it continues as part of regular care.
We will evaluate the program using the RE-AIM framework, focusing on:
- Reach: How many people engage with the program.
- Effectiveness: Changes in CC screening rates.
- Adoption: Integration into clinic operations.
- Implementation outcomes: Acceptability, feasibility, fidelity, and cost-effectiveness.
- Maintenance: Long-term sustainability of the program.
Discussion
This study is among the first to use a peer-driven approach to enhance CC screening. If successful, this model could be adapted for other health issues, promoting preventive health behaviors.
Trial Registration
Registered at NIH Clinical Trial Registry NCT06010160 (clinicaltrials.gov; date: 8/17/2023).
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