Background
Insulin sensitivity is important for preventing metabolic diseases, especially in adults who survived childhood cancer. The APACIS study aims to explore how two different exercise programs can improve health and metabolism in children diagnosed with cancer.
Study Methods
The APACIS trial involves children diagnosed with any type of pediatric cancer. These children are randomly assigned to one of two groups:
- Soft Group: Participates in low-intensity physical activities.
- Strong Group: Engages in mixed, high-intensity exercises.
Both exercise programs occur at least twice a week for 30 to 60 minutes over six months and are tailored to each child’s health. The study will follow up with participants for 18 months.
Goals of the Study
The main goal is to measure changes in insulin sensitivity using a specific assessment tool at different time points (0, 3, 6, 12, and 24 months). Secondary goals include:
- Changes in cholesterol and triglyceride levels
- Monitoring undernourishment
- Assessing cardiorespiratory fitness
- Measuring flexibility
- Evaluating fat distribution
- Tracking physical activity levels
The study will also analyze metabolic changes and the impact of exercise on gut and oral microbiota.
Discussion
The APACIS study aims to understand how different exercise intensities affect metabolism, movement, and nutrition in children with cancer, starting these activities from the time of diagnosis. This research could lead to more personalized exercise recommendations for young cancer patients.
Next Steps for Clinics and Patients
Based on the trial data, clinics can:
- Define measurable health outcomes for children undergoing cancer treatment.
- Set clear goals for improving metabolic health through tailored exercise programs.
- Choose AI tools that meet specific clinical needs for monitoring and managing patient health.
- Implement a step-by-step approach, starting with pilot projects to track the impact of exercise on health outcomes.
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