Study Overview: ACTOv Trial Title: Adaptive ChemoTherapy for Ovarian Cancer (ACTOv) This is a phase II study to test a new way of treating ovarian cancer using a drug called carboplatin. It focuses on women whose cancer has returned after treatment and is still sensitive to platinum-based therapies. What is Adaptive Therapy? Adaptive therapy (AT)…
Cost-Effectiveness of Metacognitive Therapy for Cardiac Rehabilitation Study Overview The study examines the effectiveness and cost of metacognitive therapy (MCT) combined with usual care (UC) for patients with cardiovascular disease (CVD) experiencing anxiety and/or depression. The goal is to see if MCT is a better option than just UC. Research Method A multicenter, single-blind, randomized…
Improving Emergency Department Referrals for Chest Pain: URGENT 2.0 Trial Overview Ischaemic heart disease is the leading cause of death globally. Identifying patients with serious heart issues during prehospital care for chest pain is often difficult for doctors and paramedics. Less than 20% of chest pain patients sent to the emergency department (ED) actually have…
Impact of Alternative Diagnostic Labels for Melanoma In Situ Introduction Melanoma in situ has a low risk for life and health. However, current names make it hard for patients to understand the risks compared to more serious melanomas. This study will test if using different names affects patient decisions and anxiety. Study Methods This study…
STARLIT-2 Study Overview Introduction Cortisol is a vital hormone for managing stress. When the body fails to produce enough cortisol, it leads to a condition called adrenal insufficiency (AI), which can be life-threatening. The current test for diagnosing AI, the Short Synacthen Test (SST), is invasive and costly. There is a need for a non-invasive…
A Phase II Clinical Trial for MCAP Syndrome: The SESAM Study Introduction Megalencephaly capillary malformation polymicrogyria (MCAP syndrome) is caused by specific genetic changes. Key symptoms include large head size, growth issues, developmental delays, and brain abnormalities. Alpelisib (Vijoice) is a new treatment approved for related conditions. This study aims to see how effective alpelisib…
Echocardiographic Phenotypes of Diabetic Myocardial Disorder Overview Diabetic myocardial disorder (DbMD) is a significant condition linked to heart failure. It is measured through echocardiograms or cardiac biomarkers. This study looks at how DbMD evolves over 15 months in patients with heart failure at an early stage. Study Objective The goal was to examine the changes…
Study Overview: Computerized vs. Manual Acupuncture for Knee Osteoarthritis Background Knee osteoarthritis (KOA) is a common condition that leads to pain and difficulties in movement. Acupuncture might help, but the traditional way of choosing acupuncture points isn’t standardized. The Acugraph system uses computers to find these points, which may improve treatment accuracy. Objective This study…
Androgen Receptor Pathway Inhibitor Therapy for Advanced Prostate Cancer Key Findings from a Clinical Trial Importance: The LACOG0415 trial studied three treatment options for patients with advanced castration-sensitive prostate cancer (CSPC): Androgen deprivation therapy (ADT) plus abiraterone acetate and prednisone (AAP) Apalutamide (APA) alone APA combined with AAP Objective: The study aimed to see how…
Comparison of PDO Screw Threads and Fractional CO2 Laser for Acne Scars Study Overview This study focuses on treating atrophic acne scars, which are difficult to manage. We compared two methods: subcision with PDO screw threads and subcision with fractional CO₂ laser. Both methods were tested on 40 patients to see which one worked better…
Evaluation of a Rehabilitation Program for Melanoma Patients Study Purpose The study aimed to see how a comprehensive rehabilitation program affects the health of melanoma patients after surgery. It focused on improving physical health, emotional well-being, and reducing complications. Methods A total of 148 melanoma patients participated in the study. They were randomly divided into…
A Phase 3 Study of Socazolimab for Small Cell Lung Cancer Overview This study tested the effectiveness of socazolimab combined with chemotherapy in treating extensive-stage small cell lung cancer (ES-SCLC). It involved 54 hospitals in China and included 498 adults who had never received treatment for this condition. Study Details Participants were randomly assigned to…
Study Overview This study compared the effectiveness of two treatments for chronic migraines: greater occipital nerve (GON) block and pulsed radiofrequency (PRF) therapy. Key Details Participants: 70 patients with chronic migraines were included. Methods: Patients were divided into two groups: one received GON blocks and the other received PRF therapy. Assessment: Pain relief and disability…
Evaluation of Treatments for Myofascial Pain Study Overview This study looked at how effective occlusal splints and muscle injections are for patients with myofascial pain, a common issue in temporomandibular joint disorders (TMD). Key Findings Participants: 64 patients diagnosed with myofascial pain were divided into four groups. Treatment Groups: Group 1: Occlusal splint only Group…
Tapinarof Cream 1% for Atopic Dermatitis Tapinarof cream 1% applied once daily is safe and effective for both adults and children with atopic dermatitis, based on two phase 3 trials. Study Overview In the ADORING 1 and 2 trials, patients aged 2 years and older used Tapinarof or a placebo cream daily for 8 weeks.…
Therapeutic Effects of Chiglitazar and Rosa Roxburghii in Patients with Metabolic Syndrome Study Overview This study aimed to assess how effective Chiglitazar, when combined with Rosa roxburghii Tratt (RRT), is for inpatients with psychiatric disorders suffering from antipsychotic-induced metabolic syndrome (MetS). A total of 100 patients participated, split into two groups: one receiving only Chiglitazar…
Young, Empowered & Strong (YES) Study Overview Background Adolescents and young adults (AYAs) with breast cancer face more aggressive disease and require intensive treatment, which disrupts their lives. They often have unmet needs related to: Symptoms: Issues like sexual problems, anxiety, fatigue, stress, and hot flashes. Concerns: Topics such as fertility, genetics, relationships, and financial…
Effectiveness of School Dental Screening Program on Children’s Dental Health Study Overview This study looked at how school dental screenings and different referral systems affect dental health in children aged 6-11. Aim of the Study The goal was to check if referring children to a specific dental hospital after school screenings could lower dental issues…
Parallel Randomised Trial on Community Fibrosis Assessment for Non-Alcoholic Fatty Liver Disease Objective Non-alcoholic fatty liver disease (NAFLD) affects about one-third of adults in Australia, and its numbers are expected to grow. This increase poses a challenge for healthcare systems. The LOCATE-NAFLD trial aimed to create a community-based service using FibroScan to speed up the…
Reduced Contrast Agent Volume in Coronary CTA for COPD Patients Study Overview This study focuses on a new scanning method that uses less contrast agent for coronary computed tomography angiography (CTA) in patients with chronic obstructive pulmonary disease (COPD). Key Findings Personalized Protocol: A heart-rate dependent and free-breathing scanning approach significantly lowers the amount of…