The Effect of Local Anaesthetic Agents on Opioid Use and Recovery in Patients Undergoing Open Heart Surgery BMC Cardiovasc Disord. 2025 Feb 1;25(1):72. Background After open heart surgery, patients often suffer from significant pain at the incision site and around chest tubes, which can slow recovery. This study aimed to see how local anaesthetic applied…
Annual versus Less Frequent Mammographic Surveillance in Older Women with Breast Cancer Study Overview This study, known as Mammo-50, examined whether having mammograms less often than once a year is just as effective for breast cancer survival in women aged 50 and older. Key Methods The trial involved 5,235 women across 114 hospitals in the…
Can Citicoline and Vitamin B12 Help Heal Corneal Nerves After Cross-Linking? Study Overview This study looked at how topical citicoline, vitamin B12, and hyaluronic acid (OMK2 eye drops) affect the healing of corneal nerves after corneal cross-linking (CXL) in patients with keratoconus (KC). Study Details A total of 44 eyes from 22 patients with KC…
Measuring Change in Apathy Symptoms in Alzheimer’s Disease Trials Study Overview This study focused on participants with Alzheimer’s disease (AD) to determine the minimal clinically important difference (MCID) in apathy symptoms using three different scales. Trial Design The research involved analyzing changes in apathy scores from two trials: the Apathy in Dementia Methylphenidate Trial (ADMET)…
Study Overview This study compares two methods for diagnosing unknown causes of fluid in the lungs: medical thoracoscopy (MT) and closed pleural biopsy (CPB). Background Medical thoracoscopy is popular for diagnosing lung fluid issues, but it’s not commonly available in developing countries like India. Aims 1. To compare the effectiveness of CPB and MT in…
Study Overview This study compares diagnoses made with a computerized diagnostic decision support system (CDDSS) to traditional diagnoses in emergency patients. It was conducted in multiple emergency departments in Switzerland. Key Points Purpose: To determine if CDDSS improves diagnostic accuracy in emergency settings. Participants: 1,204 adults with specific symptoms were included in the study. Method:…
Early Detection and Treatment for Postpartum Haemorrhage Overview Postpartum haemorrhage is a major cause of maternal death. A study called E-MOTIVE showed that a specific intervention could reduce serious outcomes by 60%. This intervention involves: Using special blood-collection drapes to detect bleeding early. A treatment bundle that includes uterine massage, medications, and fluids. Support strategies…
Free Interleukin 18 (IL-18F) Blood Levels After Midline Laparotomy Study Overview This study examined the blood levels of free IL-18 (IL-18F) and other important markers in patients undergoing midline laparotomy (MLa). We compared patients with benign diseases and those with cancer to see how these levels relate to pain. Key Findings IL-18F levels decreased significantly…
Protocol for Evaluating Music Integration in Taekwondo for Children with Autism Overview This study aims to understand how adding music to Taekwondo training can help children with autism spectrum disorder (ASD) improve their motor skills and engagement in physical activities. Background Children with ASD often struggle with movement coordination. While exercise programs have shown positive…
The Role of Serum Free Fatty Acids in Microvascular Function Background High levels of serum free fatty acids (FFA) are linked to insulin resistance and are common in metabolic syndrome. Insulin resistance often leads to poor blood vessel function. Objective We aimed to see if lowering FFA using two different medications—acipimox and salsalate—could improve blood…
Addressing the Fear of Cancer Recurrence in Family Caregivers Study Overview This study focuses on the fear of cancer recurrence (FCR) experienced by family caregivers (FC) of cancer patients. FCR can lead to a lower quality of life and increased psychological distress. The goal was to test the Family Caregiver-Fear Of Recurrence Therapy (FC-FORT) to…
Automatic Quality Control System and Adenoma Detection Rates During Routine Colonoscopy Study Overview This clinical trial examined how an Automatic Quality Control System (AQCS) can improve adenoma detection rates during colonoscopy, which is crucial for reducing colorectal cancer risks. Key Findings Higher Detection Rates: The AQCS-assisted colonoscopy group had a significantly higher adenoma detection rate…
Intermittent Fetal Heart Monitoring with Moyo Doppler Improving Fetal Heart Rate Detection in Ethiopia Study Purpose: This study aimed to evaluate how effective intermittent fetal heart rate (FHR) monitoring with the Moyo Doppler is compared to the traditional fetoscope in Ethiopian hospitals in 2023. Background: The Moyo FHR monitor was introduced to help quickly identify…
Addressing Unknown Primary Cancer with Early Diagnosis — The SUPER-ED Trial Background Patients with malignancy of undefined origin (MUO) face serious challenges, including poor outcomes and lengthy diagnostic processes. This often leads to patient distress and increased healthcare costs. Without a known primary diagnosis, timely treatment is delayed. Our goal is to enhance the diagnostic…
Prognostic Value of Angiography-Derived Index of Microcirculatory Resistance Study Overview This study investigates how the angiography-derived index of microcirculatory resistance (angio-IMR) relates to outcomes in patients with intermediate coronary stenosis. Key Findings The study involved 1,658 patients from the FLAVOUR trial. Patients were monitored for 24.8 months on average. Those with angio-IMR >25 had a…
Statistical Analysis Plan for ANDROMEDA-SHOCK 2 Clinical Trial Background: The ANDROMEDA-SHOCK 2 trial is an international study comparing targeted resuscitation based on hemodynamic phenotype and capillary refill time to standard care in patients with early septic shock. The goal is to see if this targeted approach leads to lower complications and deaths. Objective: To outline…
Minimally Invasive Surgery for Low-Risk Cervical Cancer Study Overview This study examines whether minimally invasive surgery (MIS) is safe for women with low-risk cervical cancer who have undergone simple hysterectomy. It builds on previous findings that showed worse outcomes for MIS in early-stage cervical cancer patients. Research Methods The analysis included 338 patients from the…
Exploring the Impact of Short Videos on Mental Health Help-Seeking in Young People Introduction Many young people do not seek help when experiencing early psychosis. This study looked at how short, informative videos could change their attitudes towards getting mental health care. Methods In this online study, 147 participants were divided into groups. They watched…
Exercise Medicine to Enhance Cancer Treatment: The ERADICATE Study Overview The ERADICATE study explores how exercise can improve the effectiveness of radiation therapy for prostate cancer. Tumors often lack sufficient blood flow, leading to treatment resistance. This study aims to see if exercise can help by improving blood flow and reducing tumor hypoxia. Study Design…
Community Benefits of Dual-Active-Ingredient Insecticidal Nets Against Malaria in Tanzania Background Long-lasting insecticidal nets (LLINs) were effective against malaria, but mosquitoes have become resistant to the main insecticides used. To address this, new dual-active ingredient LLINs (dual-AI LLINs) have been introduced. It’s essential to know how much these nets need to be used in a…