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Ten sessions of hyperbaric oxygen versus sham treatment in patients with long covid (HOT-LoCO): a randomised, placebo-controlled, double-blind, phase II trial

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Study Overview

This study aimed to see if 10 sessions of hyperbaric oxygen therapy (HBOT) could improve the health and quality of life for patients suffering from long COVID compared to a placebo treatment.

Study Design

The research was a double-blind, placebo-controlled trial conducted at a university hospital in Sweden. It involved healthy adults aged 18-60 who had long COVID. Pregnant women and those with certain health conditions were excluded.

Participants and Treatment

A total of 80 participants were randomly assigned to receive either HBOT or a placebo treatment over 6 weeks. The HBOT used 100% oxygen, while the placebo used medical air.

Results

After 13 weeks, both groups showed improvements in their health, but there was no significant difference between those receiving HBOT and those receiving placebo. The study analyzed 79 participants, with 40 in the HBOT group and 39 in the placebo group.

Adverse Events

There were some side effects reported, including cough and chest discomfort. Both groups experienced similar rates of adverse events, with one serious incident in the HBOT group and one death in the placebo group.

Conclusions

The study concluded that 10 sessions of HBOT did not provide more benefits than the placebo for patients with long COVID. However, both groups showed improvements, and the side effects were manageable.

Opportunities for Clinics and Patients

  • Measurable Outcomes: Set clear goals for patient health improvements based on trial data.
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