The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
Study Overview
Curcumin, derived from turmeric root, has been found to have anti-inflammatory effects, and this study aimed to assess its potential in reducing the risk of atherosclerosis in obese patients with type 2 diabetes. The trial, involving 227 participants, utilized a randomized, double-blind, placebo-controlled design to evaluate the impact of curcumin over a 12-month period.
Key Findings
After 12 months, participants receiving curcumin demonstrated a significant reduction in pulse wave velocity (p < 0.001) and saw decreased levels of cardiometabolic risk biomarkers, including low-density lipoprotein cholesterol and small dense low-density lipoprotein cholesterol, all with p values less than 0.001. Additionally, markers of inflammation, such as high-sensitivity C-reactive protein, interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha, were significantly lower in the curcumin group (p values < 0.001).
The study concluded that curcumin intervention was associated with a reduction in pulse wave velocity and an improvement in cardiometabolic risk profiles, suggesting that curcumin treatment may effectively reduce atherogenic risks in type 2 diabetes patients with obesity.
Value in Healthcare
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