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A Comparison of Stockholm3, Serum Biomarkers, and Risk Calculators to Predict Prostate Cancer in a Racially and Ethnically Diverse Cohort: Evaluation of the Stockholm3 Multiethnic SEPTA Trial

Purpose of the Study

The study aimed to evaluate how well the Stockholm3 test predicts prostate cancer compared to other common tests and risk calculators.

Study Overview

This was a large trial conducted from 2019 to 2023, involving a diverse group of men who were eligible for prostate biopsy. A total of 2115 men participated, providing complete data for analysis.

Key Findings

Among the participants:

  • The average age was 63 years.
  • The average PSA level was 6.1 ng/mL.
  • 20% had a previous negative biopsy.
  • 17% underwent an MRI before the biopsy.

The results showed:

  • 56.7% of biopsies were benign.
  • 14.5% were Grade Group 1 cancers.
  • 28.8% were Grade Group ≥ 2 cancers.

The Stockholm3 test performed significantly better than other tests, with a higher accuracy rate for detecting serious cancers.

Benefits of Stockholm3

Using Stockholm3 could lead to a 44% reduction in unnecessary biopsies while still detecting 95% of significant cancers.

Conclusions

The Stockholm3 test is more effective than other commonly used tests for identifying serious prostate cancer in a diverse population.

Opportunities for Clinics and Patients

Define Measurable Outcomes

Set clear goals based on the study to improve cancer detection rates in clinics.

Select AI Tools That Fit Clinical Needs

Choose AI solutions that are specifically designed for tasks related to prostate cancer detection.

Implement Step by Step and Expand

Start with a pilot project using AI solutions, monitor the results, and assess the real-world impact based on the trial findings.

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