A randomized translational study on protein- and glucose metabolism in skeletal muscles evaluated by gene-ontology, following preoperative oral carbohydrate loading compared to overnight peripheral parenteral nutrition (PPN) before major cancer surgery

Study on Preoperative Nutrition for Cancer Surgery Patients

Key Findings

Comparing the effects of preoperative nutrition drink and overnight parenteral nutrition on muscle metabolism in patients undergoing major gastrointestinal cancer surgery.

Results

The study found that the preoperative nutrition drink had limited impact on muscle metabolism, particularly in glucose metabolism. On the other hand, overnight parenteral nutrition showed significant positive effects on amino acid and protein metabolism, including inhibition of muscle protein degradation.

Practical Solutions

Conventional overnight preoperative parenteral nutrition appears to be more effective in improving muscle protein metabolism in patients undergoing major cancer surgery, compared to preoperative oral carbohydrate loading. This suggests that the latter may not be recommended before major cancer surgery.

Value

These findings provide valuable insights for clinicians and may have implications for enhanced recovery after surgery (ERAS) protocols.

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