Adherence to a low-fat dietary pattern reduces head and neck cancer risk: evidence from the PLCO trial

Adherence to a Low-Fat Diet Lowers Head and Neck Cancer Risk

Study Overview

The study focused on how a low-fat dietary pattern (LFD) affects the risk of head and neck cancer (HNC). A low-fat diet means eating less fat overall.

Study Methods

The research used data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Participants’ adherence to a low-fat diet was measured using a scoring system, with higher scores showing better adherence. Statistical methods were used to analyze the link between diet and cancer risk, and various subgroup analyses were conducted to ensure accuracy.

Key Findings

  • Out of 98,459 participants, 268 developed head and neck cancer during an average follow-up of 8.8 years.
  • Those with the highest adherence to a low-fat diet had a significantly lower risk of HNC (HR Q4 vs. Q1: 0.60) and larynx cancer (HR Q4 vs. Q1: 0.46).
  • The results show a clear link between a higher LFD score and lower cancer risk.

Conclusion

This study suggests that following a low-fat diet may reduce the risk of head and neck cancer in the U.S. population.

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