Assessment of Safety in Diagnosing Interstitial Lung Disease
Rationale and Objectives
Bleeding is a common complication of transbronchial lung cryobiopsy (TBLC). This study aimed to determine if pre-placing a bronchial balloon during TBLC for diagnosing interstitial lung disease (ILD) is safer and more effective in preventing bleeding.
Materials and Methods
Patient with suspected ILD were enrolled in a randomized controlled trial. They were assigned to either a pre-placed balloon group or a none-pre-placed balloon group. The primary outcome was the incidence of moderate bleeding, with secondary endpoints including severe bleeding, pneumothorax, and other complications.
Results
250 patients were enrolled, with no significant difference in severe bleeding between the two groups. However, more moderate bleeding occurred in the none-pre-placed balloon group, along with a higher use of hemostatic drugs. The pre-placed balloon group also had better sample acquisition.
Conclusion
Pre-placing a bronchial balloon can reduce the incidence of moderate bleeding and improve bronchoscopist confidence. However, it did not affect the diagnostic rate or reduce severe bleeding.
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