Budesonide Attains Its Wide Clinical Profile by Alternative Kinetics

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Practical Solutions and Value of Budesonide in Asthma Treatment

Key Points:

  • Inhaled corticosteroids (ICSs) revolutionized the treatment of mild-to-moderate asthma by focusing on reducing inflammation in the airways.
  • Budesonide (BUD) offers a unique clinical profile due to its alternative kinetics, providing practical solutions for effective asthma management.
  • Its high water solubility allows for rapid intraluminal dissolution within the airways, leading to faster airway and systemic uptake rates.
  • BUD’s reversible esterification to intracellular fatty acids prolongs its efficacy in airway tissue, while its rapidly absorbed bulk fraction adds anti-inflammatory activity at the blood and bone marrow levels.
  • Controlled clinical trials have established BUD as a first-line treatment for asthma, suitable for patients with all degrees of severity.
  • The development of the budesonide/formoterol combination inhaler (BUD/FORM) has contributed to widely used maintenance and reliever therapy (MART) and as-needed therapy for asthma (“anti-inflammatory reliever”, AIR).
  • These qualities have significantly influenced international asthma management and treatment guidelines.

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Full research Budesonide Attains Its Wide Clinical Profile by Alternative Kinetics: https://pubmed.ncbi.nlm.nih.gov/38675463/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1B1L42DK3a-JWCV4P_PtHHBmWjwBLFNcDXsYJkbqjQD0Ca7UQh&fc=None&ff=20240427133354&v=2.18.0.post9+e462414

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