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Practical Solutions and Value of Budesonide in Asthma Treatment
Key Points:
- Inhaled corticosteroids (ICSs) revolutionized the treatment of mild-to-moderate asthma by focusing on reducing inflammation in the airways.
- Budesonide (BUD) offers a unique clinical profile due to its alternative kinetics, providing practical solutions for effective asthma management.
- Its high water solubility allows for rapid intraluminal dissolution within the airways, leading to faster airway and systemic uptake rates.
- BUD’s reversible esterification to intracellular fatty acids prolongs its efficacy in airway tissue, while its rapidly absorbed bulk fraction adds anti-inflammatory activity at the blood and bone marrow levels.
- Controlled clinical trials have established BUD as a first-line treatment for asthma, suitable for patients with all degrees of severity.
- The development of the budesonide/formoterol combination inhaler (BUD/FORM) has contributed to widely used maintenance and reliever therapy (MART) and as-needed therapy for asthma (“anti-inflammatory reliever”, AIR).
- These qualities have significantly influenced international asthma management and treatment guidelines.
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