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Clinical effects of stannous fluoride dentifrice on peri-implant mucositis, plaque microbiome, and oxidative stress

Study Overview

This study looked at how effective a stannous fluoride (SnF₂) toothpaste is for treating peri-implant mucositis, a condition that causes inflammation around dental implants. The study lasted 4 weeks and involved 24 healthy participants.

Participants

Among the 24 participants, 19 had mucositis, while 5 did not and served as a comparison group. All participants used the same SnF₂ toothpaste twice a day.

Methods

The researchers assessed gum health and collected samples to measure inflammation and changes in bacteria in the mouth at the start and after 4 weeks.

Results

After 4 weeks, participants with mucositis showed:

  • A significant decrease in gum inflammation scores (63.4% reduction).
  • A major reduction in bleeding from gums (72.5% reduction).
  • A shift in the types of bacteria present, moving toward a healthier balance.
  • A decrease in markers related to inflammation and bacterial damage.

Clinical Significance

This study suggests that using SnF₂ toothpaste can effectively reduce signs of peri-implant mucositis and improve the overall health of the oral microbiome.

Practical Applications

Based on these findings, clinics can aim to:

  • Monitor improvements in gum health using specific measurable outcomes.
  • Set clear goals for reducing inflammation and improving oral health.
  • Utilize AI tools for tracking patient progress and treatment effectiveness.
  • Start with small pilot projects to see real-world impact before wider implementation.

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