Comparison of Zuberitamab Plus CHOP vs. Rituximab Plus CHOP for DLBCL Treatment
Study Overview
This study aimed to compare the effectiveness and safety of zuberitamab plus CHOP against rituximab plus CHOP in patients with untreated CD20-positive diffuse large B-cell lymphoma (DLBCL).
Methods
Patients were randomly assigned to receive six cycles of either zuberitamab or rituximab along with standard CHOP chemotherapy. The main goal was to assess the objective response rate (ORR) after treatment. Secondary goals included complete response rates, duration of response, progression-free survival, and safety evaluations.
Results Summary
Out of 487 patients, 423 completed the assessment. Key findings include:
- ORR: 83.5% for zuberitamab plus CHOP vs. 81.4% for rituximab plus CHOP.
- Complete Response Rate: Higher in zuberitamab group (85.7% vs. 77.3%).
- Survival Rates: Slightly better outcomes in the zuberitamab group for duration of response, progression-free survival, and overall survival.
- Adverse Events: Similar rates across groups, but infusion-related reactions were more common with zuberitamab.
Conclusions
Zuberitamab plus CHOP is a promising treatment option for DLBCL, showing comparable efficacy to rituximab plus CHOP, with a higher complete response rate and good tolerability.
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