Drug Development
Study Overview
This clinical trial examined the use of transcutaneous vagus nerve stimulation (tVNS) to help improve memory and cognitive function in participants with mild cognitive impairment (MCI).
Trial Details
The study had a randomized, double-blind, placebo-controlled crossover design. A total of 59 participants with MCI were divided into two groups: one received tVNS, while the other received a sham treatment. The sham treatment involved electrodes placed on the earlobes without actual stimulation.
Stimulation Process
In the tVNS condition, electrodes were correctly positioned on the nerve area. The stimulation settings were consistently applied, and neuropsychological tests were conducted during the treatment sessions to evaluate cognitive performance.
Results
The trial found that there was no significant improvement in memory recall or cognitive performance from tVNS compared to the sham treatment.
Conclusion
Overall, a single session of tVNS does not seem to be an effective method for enhancing cognitive function in people with MCI.
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