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Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a randomized controlled trial

Background

This study looked at how certain diabetes medications combined with a high-protein diet and moderate exercise can help people with obesity and newly diagnosed prediabetes or type 2 diabetes lose weight and possibly reverse their diabetes.

Methods

A total of 61 participants with obesity and recent diagnoses were split into two groups. One group received standard treatment (medications and lifestyle advice) for a year, while the other group received the same treatment plus a high-protein diet and moderate exercise routine.

Results

By the end of the study, 60 participants completed the follow-up. In the group that followed the high-protein diet and exercise,:

  • 73.33% of those with prediabetes returned to normal blood sugar levels.
  • 86.67% of those with type 2 diabetes achieved remission.

In contrast, only 7.69% of the prediabetes group and 16.67% of the diabetes group in the standard treatment achieved remission.

Participants in the intensive treatment group lost an average of 19.29 kg, while those in the standard treatment group lost only 1.52 kg. Other health markers, such as body fat and liver health, also improved significantly in the intensive group.

Conclusions

The combination of diabetes medications, a high-protein diet, and moderate exercise can help a significant number of patients with type 2 diabetes achieve remission.

Practical Steps for Clinics and Patients

Define Measurable Outcomes

Set clear targets for weight loss and improvement in diabetes status based on these findings.

Select AI Tools That Fit Clinical Needs

Choose AI solutions designed to enhance the management of diabetes and weight loss interventions.

Implement Step by Step

Start with a pilot project using these approaches, track the outcomes, and assess the real-world impact.

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