Effects of Esketamine on Postoperative Fatigue Syndrome in Patients after Laparoscopic Resection of Gastric Carcinoma: A Randomized Controlled Trial
Background
Despite various postoperative management strategies, postoperative fatigue syndrome (POFS) remains common in patients undergoing laparoscopic radical gastrectomy. Esketamine, an N-methyl-D-aspartic acid receptor antagonist, has shown effectiveness in improving sleep quality and reducing postoperative pain. However, its impact on POFS is uncertain.
Methods
A total of 133 gastric cancer patients were randomly assigned to two groups: the control group (Group C) and the esketamine group (Group E). Group C received standard anesthesia, while Group E received esketamine in addition to standard anesthesia. The primary outcome measure was the Christensen fatigue score at 3 days after surgery, with secondary outcomes including disparities in postoperative fatigue, pain, sleep quality, and adverse reactions.
Results
Patients receiving esketamine showed significantly lower fatigue scores on the third day after surgery compared to Group C. There was also a significant decrease in fatigue occurrence on the first and third days post-surgery in Group E. Additionally, Group E exhibited reduced postoperative pain and improved sleep compared to Group C, with similar rates of adverse events in both groups.
Conclusions
Perioperative administration of esketamine can effectively improve POFS after laparoscopic radical gastrectomy without adverse reactions.
Trial Registration
Registered in the Chinese Clinical Trial Registry (ChiCTR2300072167) on 05/06/2023.
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