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Effects of probiotic and vitamin D co-supplementation on clinical symptoms, mental health, and inflammation in adult patients with migraine headache: a randomized, triple-blinded, placebo-controlled trial

Effects of Probiotic and Vitamin D Co-Supplementation on Migraine

Study Overview

This study explores how taking probiotics and vitamin D together can help adults with migraine headaches. It focuses on improving migraine symptoms, mental health, and inflammation levels.

Background

Migraine headaches are a significant health issue. Current migraine medications do not work for everyone and can cause side effects. This research aims to see if vitamin D and probiotics can improve migraine symptoms and overall well-being.

Study Method

In this trial, 72 adults aged 18 to 55 with diagnosed migraines participated. They were divided into two groups: one received vitamin D (50,000 IU every two weeks) and probiotics (4.5 × 1011 CFU daily), while the other received a placebo for 12 weeks. Researchers used questionnaires to assess headache impact and mental health at the start and end of the study. They also tracked headache frequency, duration, and severity using a 30-day diary.

Key Findings

  • Participants taking probiotics and vitamin D had a significant increase in vitamin D levels.
  • This group experienced a greater reduction in the frequency and severity of migraines compared to the placebo group.
  • No significant changes were observed in headache duration or mental health scores between the two groups.

Conclusions

The study suggests that taking probiotics and vitamin D together for 12 weeks can positively affect migraine symptoms. More research is needed to confirm these results.

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