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Efficacy of lactoferrin in preventing recurrent urinary tract infections in pregnant Egyptian women: a randomized controlled trial

Overview of the Study

This study focuses on preventing urinary tract infections (UTIs) in pregnant women, especially given the high use of antibiotics. Lactoferrin (Lf), a natural protein, has shown promise in fighting bacteria, particularly E. coli, which commonly causes UTIs. The key question was whether Lf could reduce UTI occurrences in pregnant women with a history of recurrent UTIs.

Study Details

The study took place over six months in an antenatal clinic in Alexandria, Egypt, involving 220 pregnant women who had experienced multiple UTIs recently. Participants were split into two groups: one received 200 mg of lactoferrin daily, while the other group was the control group and did not receive Lf. Women were monitored monthly for UTI symptoms and urine cultures were tested.

Results

A total of 874 urine samples were analyzed. The results showed:

  • 164 episodes of asymptomatic bacteriuria (ASB) were recorded: 33 in the Lf group vs. 131 in the control group.
  • 46 cases of acute cystitis were identified: 4 in the Lf group vs. 42 in the control group.

This indicates that Lf significantly reduced the risk of both ASB and acute cystitis by 75% and 90%, respectively. No severe cases (pyelonephritis) were found in either group.

Conclusions

The study suggests that lactoferrin could be an effective preventive measure against UTIs in pregnant women. More extensive studies are needed to confirm these results across wider populations.

Practical Healthcare Solutions

Based on these findings, clinics can:

  • Set clear goals for reducing UTI incidents in pregnant patients.
  • Implement lactoferrin as a preventive treatment in high-risk groups.
  • Monitor and track outcomes to ensure effectiveness.

Next Steps

Consider initiating a pilot program using lactoferrin and utilize AI tools to analyze patient data and improve treatment outcomes. For more information on AI solutions for medical management, reach out to us:

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