High-intensity interval training improves insulin sensitivity in individuals with prediabetes

Objective

This study aimed to explore how low-volume high-intensity interval training (HIIT) and walking, compared to no exercise, affect insulin sensitivity and metabolism in individuals with prediabetes.

Study Design

Participants were divided into four groups:

  • Control group (no exercise)
  • HIIT group (3 sprint sessions of 20 seconds each, three times a week)
  • HIIT + Walking group (more than 10,000 steps daily)
  • Walking group (walking only) for 12 weeks

Methods

Insulin sensitivity was measured through an oral glucose tolerance test before and after the trial. Muscle samples were taken to assess proteins important for metabolism.

Results

Seventy sedentary individuals with prediabetes participated. Key findings included:

  • HIIT significantly improved insulin sensitivity by 18.5% compared to the control group.
  • HIIT + Walking improved insulin sensitivity by 15.7%.
  • Walking alone increased insulin sensitivity by 9.4%, which was not statistically significant.
  • HIIT + Walking showed a 28.0% increase in whole-body insulin sensitivity.
  • Walking alone increased whole-body insulin sensitivity by 42.3%.
  • HIIT alone improved whole-body insulin sensitivity by 17.0%, but this was not significant.
  • Protein levels linked to metabolism improved the most with HIIT + Walking, showing no significant change with just walking.

Conclusions

Engaging in low-volume HIIT for 12 weeks can enhance glucose control and promote important metabolic changes in the muscles of individuals with prediabetes.

Opportunities for Healthcare

Define Measurable Outcomes

Set clear goals for improving insulin sensitivity through HIIT in clinics and among patients.

Select AI Tools That Fit Clinical Needs

Choose AI solutions tailored for enhancing the implementation of HIIT and assessing outcomes effectively.

Implement Step by Step and Expand

Start with a pilot project, using AI solutions to track results effectively, and measure the real-world impact of HIIT on metabolic health.

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