Intraoral Appliance Treatment for Sleep Apnea in Elderly Patients
Study Overview
This study focuses on how an intraoral appliance (IOA) can help elderly patients with obstructive sleep apnea (OSA). OSA can lead to serious health issues due to inflammation and oxidative stress. The goal was to see if using an IOA could reduce these problems over 60 days.
Key Findings
- Participants: 9 elderly patients with OSA.
- Significant Improvements:
- Reduced Apnea and Hypopnea Index (AHI) (p=0.003)
- Lower Oxygen Desaturation Index (ODI) (p=0.038)
- Decreased levels of Interleukin-10 (IL-10) (p=0.0001)
- Reduced Advanced Oxidation Protein Products (AOPP) (p=0.038)
- Lower Thiobarbituric Acid Reactive Substances (TBARS) (p=0.0001)
- Correlations: Strong links were found between IL-10 and Nitric Oxide (NO), and between TBARS and Interleukin-6 (IL-6).
Practical Solutions and Value
This research shows that using an IOA for 60 days can effectively reduce oxidative damage and inflammation in elderly OSA patients. This treatment can lead to better health outcomes and lower the risk of cardiovascular diseases.
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