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Practical Solutions for Managing Mixed Neuroendocrine Non-Neuroendocrine Neoplasms (MiNENs)
MiNENs are complex malignant tumors found in the digestive system, consisting of both neuroendocrine and non-neuroendocrine components. The diverse nature of these tumors, including different cell types and grades, can make their diagnosis and treatment challenging.
Defining MiNEN and Addressing Confusion
- Recent changes in the naming of these tumors have caused confusion.
- It is crucial to establish a clear definition of MiNEN to guide diagnosis and treatment.
Value of Clinical Trials
- Specific clinical trials for MiNEN are lacking, making their management difficult.
- Developing a stable classification for MiNEN will facilitate the design of clinical trials.
- Long recruitment periods will be necessary due to the low incidence of MiNEN.
Practical Approach
- Analyze available evidence to tailor diagnosis and treatment based on tumor location and extent.
- Seek consensus on diagnosis to guide the development of effective treatment strategies.
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