Non-diabetes status after diagnosis of impaired glucose tolerance and risk of long-term death and vascular complications: A post hoc analysis of the Da Qing Diabetes Prevention Outcome Study

Study: Non-diabetes Status After IGT Diagnosis and Long-Term Risks

Background

The study aimed to clarify the association between years of non-diabetes status after diagnosis of impaired glucose tolerance (IGT) and the risk of long-term death and cardiovascular outcomes.

Methods and Findings

540 individuals with IGT from the Da Qing Diabetes Prevention Study were included in a post hoc analysis. Participants were monitored for 30 years after a 6-year lifestyle intervention trial. The analysis showed that maintaining non-diabetes status for at least 4 years was associated with a significant reduction in the risk of death and vascular complications.

Conclusions

The study observed that maintaining several years of non-diabetes status after IGT diagnosis was linked to a significant reduction in long-term risk of death and vascular complications. Maintaining at least 4 years of non-diabetes status may be necessary to achieve a significant risk reduction for most outcomes.

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