Conditions: Low-grade Glioma
Interventions: Drug: Tovorafenib
Sponsors: Daniel Morgenstern; The Hospital for Sick Children
Recruiting
Pilot Study of Vinblastine and Tovorafenib in Pediatric Patients With Recurrent/Progressive RAF Altered Low Grade Gliomas
AI-Powered Health Tools
Interactive AI Tools to Help You Understand Your Health
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Solutions for Smart Healthcare
Clinical Research
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Emerging Trends in Reinforcement Learning: Applications Beyond Gaming
Reinforcement Learning: Practical Applications Finance: – RL algorithms are revolutionizing investment strategies, automating portfolio management, and improving decision-making in finance. Healthcare: – RL is optimizing personalized treatment plans, robotic surgery,…
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Effect of melatonin versus placebo for prevention of delirium among medically hospitalised patients: study protocol for a single-centre, double-blinded, randomised controlled trial (project RESTORE)
“`html Introduction Delirium is a common and serious condition in older patients in hospitals. It can lead to higher death rates, longer stays in the hospital, and problems with thinking.…
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Efficacy of a Mobile Health-Based Behavioral Treatment for Lifestyle Modification in Type 2 Diabetes Self-Management: Greenhabit Randomized Controlled Trial
Efficacy of a Mobile Health-Based Behavioral Treatment for Lifestyle Modification in Type 2 Diabetes Self-Management: Greenhabit Randomized Controlled Trial Background Using digital tools can help patients with type 2 diabetes…
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A synbiotic mixture for the management of infantile colic: A randomized trial
A Synbiotic Mixture for Managing Infantile Colic Study Overview This study investigates the effectiveness of a synbiotic (Bactecal D Liquid) for infants experiencing colic, which is characterized by excessive crying…
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A Cluster Randomized Controlled Trial Comparing the Efficacy of Pre-School Language Interventions-Building Early Sentences Therapy and an Adapted Derbyshire Language Scheme
“`html Background Children’s ability to use language is crucial for their education and overall development. Aims This study aimed to compare two language programs for preschoolers: Building Early Sentences Therapy…
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This AI Paper from MLCommons AI Safety Working Group Introduces v0.5 of the Groundbreaking AI Safety Benchmark
MLCommons is a collaboration between industry and academia that aims to improve AI safety, efficiency, and accountability through rigorous measurement standards like MLPerf. The AI Safety Working Group, established in…
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Effectiveness of continuous and pulse mode of ultrasound therapy in temporomandibular disorders associated myalgia-a randomized controlled study
Understanding Ultrasound Therapy for Jaw Pain Background Temporomandibular disorders (TMD) that cause muscle pain (TMD-M) are common issues for patients. To treat these disorders effectively, it is important to understand…
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Pharmacist-Led Education Improves Symptom Control in Adults with Allergic Rhinitis
Understanding the Trial Results This study looked at how well a pharmacist-led education program helps adults with allergic rhinitis (AR), which is a common issue affecting many people. The group…
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Detection of scapholunate interosseous ligament injury using dynamic computed tomography-derived arthrokinematics: A prospective clinical trial
Detection of Scapholunate Interosseous Ligament Injury Key Findings Comparison of injury detection methods for scapholunate ligament injuries 4DCT imaging showed utility for diagnosing ligamentous wrist injury CT-derived biomarkers, arthrokinematics, were…
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Impact of Maintenance Treatment on Male Gonadal Function in Rhabdomyosarcoma Survivors
Understanding the Trial Results The study looked at how maintenance treatment with vinorelbine and oral cyclophosphamide affects the health of male reproductive organs in young patients treated for localized rhabdomyosarcoma…
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A Randomized Clinical Trial to Evaluate the Efficacy of an Oral Probiotic in Acne Vulgaris
Evaluating the Efficacy of an Oral Probiotic in Acne Vulgaris Study Details The study aimed to assess the effectiveness of an oral probiotic in treating acne vulgaris in patients aged…
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Beyond the Diagnosis: Evaluation of Quality-of-Life Measures and Family Functioning in SLC6A1-Related Neurodevelopmental Disorder
“`html SLC6A1-Related Neurodevelopmental Disorder (SLC6A1-NDD) Clinical Trial Readiness Study Overview SLC6A1-NDD is a rare genetic disorder linked to autism spectrum disorder, epilepsy, and developmental delay. Understanding the impact on patients…
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Upadacitinib as monotherapy in patients with rheumatoid arthritis and prior inadequate response to methotrexate: results at 260 weeks from the SELECT-MONOTHERAPY randomised study
Introduction The SELECT-MONOTHERAPY trial showed that upadacitinib (UPA) can be a safe and effective treatment for rheumatoid arthritis patients who didn’t respond well to methotrexate. This report highlights key findings…
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Drug Development
Drug Development Overview Background Patients with Alzheimer’s disease (AD) often face challenging neuropsychiatric symptoms, like agitation. This can lead to increased stress for caregivers and more placements in long-term care…
