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Prednisone Use and Diabetes Risk in Rheumatoid Arthritis Patients
Study Overview
A 10-year subanalysis of the BeSt study examined the association between prednisone use, disease activity score (DAS), and the development of hyperglycaemia and diabetes in early rheumatoid arthritis (RA) patients.
Key Findings
Out of 504 non-diabetic early RA patients, 6.2% developed diabetes during the study, with 35% of those having received prior prednisone treatment. Prednisone use was not found to be associated with the development of hyperglycaemia or diabetes. However, high DAS was significantly linked to an increased risk of diabetes.
Implications
The study suggests that while prednisone use was not associated with developing hyperglycaemia or diabetes, high disease activity score increased the risk of diabetes. The potential risks associated with prednisone use may have been mitigated by its effect on DAS.
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