Research Overview
This study focuses on comparing cancer regression (d) and growth (g) rates in patients with advanced castration-sensitive prostate cancer (CSPC) undergoing androgen deprivation therapy (ADT).
Purpose
The goal is to understand how different ADT regimens affect tumor behavior, which can lead to more personalized treatment plans. This comparison may also help predict patient survival outcomes.
Methods
The study analyzed data from the KYUCOG-1401 trial involving patients with advanced CSPC. They were divided into two groups: one receiving a GnRH antagonist (Group A) and the other receiving a GnRH agonist plus bicalutamide (Group B). The researchers used mathematical models to estimate d and g rates and compared these rates among different patient subgroups.
Results
- Patients with higher PSA levels and disease extent showed greater d rates.
- The median d rate was lower in Group A compared to Group B.
- The median g rate was higher in Group A compared to Group B.
- The growth rate (g rate) was a better predictor of survival outcomes than the regression rate (d rate).
Conclusion
The study suggests that GnRH agonist plus bicalutamide is more effective in lowering PSA levels quickly and maintaining these lower levels compared to GnRH antagonists. Measuring the g rate can enhance predictions for PSA progression-free survival, radiographic progression-free survival, and overall survival in patients with advanced CSPC. Incorporating g rate measurements into practice could significantly improve treatment planning and patient outcomes.
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