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Introduction

Lower urinary tract infections (UTIs) are common, affecting almost two-thirds of women at some point in their lives. Many experience recurrent infections. Although there are guidelines for treating UTIs, not all healthcare providers follow them closely.

Aim of the Study

This study aimed to evaluate the immediate results of treating acute uncomplicated cystitis in working-age women living in a large industrial city with challenging environmental conditions.

Study Overview

A multicenter study involved 440 women with acute uncomplicated cystitis from four outpatient clinics in Perm. All participants received a single dose of the antibiotic fosfomycin trometamol (3 g). They were divided into four groups for treatment:

Group 1: Received only fosfomycin trometamol.
Group 2: Fosfomycin trometamol plus drotaverine (80 mg three times a day for two days).
Group 3: Fosfomycin trometamol plus phenazopyridine (200 mg three times a day for two days).
Group 4: Fosfomycin trometamol plus Canephron N (2 tablets three times a day for six days).

Results

The study found that 97.2% of bacteria were sensitive to fosfomycin. Here are the recovery rates for each group:

Group 1: 92.5% recovered, but pain relief was slow.
Group 2: No significant improvement.
Group 3: 97.3% recovered with fast pain relief and a disability period of about 5.1 days.
Group 4: 96.4% recovered with similar results to Group 3.

Overall, fosfomycin trometamol led to a recovery rate of 95.2% with minimal side effects (1.1%).

Conclusions

Fosfomycin trometamol is a highly effective and safe treatment for acute uncomplicated cystitis, even in challenging environments. Combining it with urinary analgesics and herbal remedies like Canephron N can enhance symptom relief.

Future Opportunities

Clinics can set measurable goals based on these results, such as improving recovery rates and reducing the time patients are disabled. AI tools can help track these outcomes effectively.