Clinical Trials

Background Expanding malaria community case management (mCCM) to all ages can improve access to healthcare in areas that need it the most. This study looked at how practical and cost-effective this change would be in the Farafangana district of Madagascar. Study Methods Researchers conducted a trial across 30 health centers involving 502 community health workers […] ➡️➡️➡️

Study Overview This study looked at how effective three different treatments are for patients with lateral epicondylitis (commonly known as tennis elbow). Treatment Groups Fifty-four patients were randomly divided into three groups: Epicondylitis bandaging Wrist dorsiflexion splinting Kinesio taping Patient Assessment Patients were evaluated using: Visual Analog Score (VAS) – for pain level Disabilities of […] ➡️➡️➡️

“`html Purpose This study aimed to compare the effectiveness of two methods for draining subretinal fluid during surgery for retinal detachment. Methods We looked at 43 patients with retinal detachment, dividing them into two groups: Group A: 22 patients received internal drainage using a special tool. Group B: 21 patients received external drainage during surgery. […] ➡️➡️➡️

Study Overview This study compared a new robotic-assisted navigation system with traditional methods for taking biopsies of tumors in the chest and abdomen. It involved 140 patients who needed this procedure. Results Success Rate: The robotic system successfully located the biopsy site 84.1% of the time, compared to just 43.7% for the traditional method. Adjustment […] ➡️➡️➡️

Background Recent studies show that blood tests can help diagnose and predict the progression of Alzheimer’s disease (AD), especially in its early stages. This research aimed to explore how these blood markers can forecast outcomes in patients with mild to moderate AD. Methods We analyzed data from a clinical trial called T2 Protect AD, which […] ➡️➡️➡️

“`html Background Oral mucositis (OM) is a painful condition that many children face when undergoing chemotherapy. This clinical trial tested two treatments: photobiomodulation (PBM) to prevent OM and photodynamic therapy (PDT) to treat it in children with blood cancers. Methods In the prevention phase, some patients did not receive PBM initially but were given it […] ➡️➡️➡️

Study Overview This study investigates how using a collagen sponge in the socket after removing impacted lower third molars affects pain, mouth opening, and the risk of dry socket (Alveolar Osteitis). Study Method Researchers conducted a randomized trial with patients who had teeth removed from both sides of their mouths. On one side, they applied […] ➡️➡️➡️

Objective This study aimed to see how well cariprazine helps reduce anxiety symptoms in adults diagnosed with major depressive disorder (MDD) who did not respond well to other antidepressants. Methods We looked at data from a large study with 751 participants. We focused on how cariprazine at doses of 1.5 mg and 3.0 mg per […] ➡️➡️➡️

Background and Objective Measuring breathlessness in early-stage lung cancer can be tricky because different scales may give varying results. This study looks at three common scales: the Modified Borg Scale (mBorg), the Numerical Rating Scale (NRS), and the Dyspnea-12 scale (D-12). The goal is to find out how these scales agree with each other and […] ➡️➡️➡️

Background American Indians face significant health challenges, particularly high rates of Type 2 diabetes (T2D). To address this issue, we launched a program called Together Overcoming Diabetes (TOD), which focuses on culturally relevant, home-based prevention strategies. Study Overview This study involves collaboration between five tribal nations and university researchers, starting in 2021. We are conducting […] ➡️➡️➡️

Background Excess fat in the liver can lead to a condition called metabolic dysfunction-associated steatotic liver disease (MASLD). This study looked at how weight loss affects fat buildup in the liver. Study Overview Overweight adults with either high or normal liver fat were given dietary counseling for 6 months. Researchers measured various factors to understand […] ➡️➡️➡️

Understanding Acute Pancreatitis Acute pancreatitis (AP) is a serious condition that needs quick diagnosis and treatment. Correctly assessing how severe the condition is helps in providing the right care at the start. Aim of the Study This study looks at how effective certain inflammatory markers and scoring systems are in determining the severity of early-phase […] ➡️➡️➡️

Overview of the Study Total knee arthroplasty (TKA) is important for relieving pain and enhancing life quality in patients with severe knee arthritis. However, many patients experience sleep problems after surgery, which can last for months and affect recovery. Robotic-Assisted TKA vs. Conventional TKA This study compared sleep quality in patients who underwent robotic-assisted TKA […] ➡️➡️➡️

Study Overview This study aims to explore the benefits of acupuncture for people suffering from diarrhoea-predominant irritable bowel syndrome (IBS-D). Although some research suggests acupuncture may help, there are not many high-quality studies available. We want to find out how effective and safe personalised acupuncture is for IBS-D patients. Study Design The research will involve […] ➡️➡️➡️

Background In patients with acute myeloid leukaemia (AML), finding measurable residual disease (MRD) usually means a poor outlook. This study looked at whether changing treatment based on MRD results could help patients live longer. Methods We studied patients aged 16-60 with newly diagnosed AML in the UK, Denmark, and New Zealand. We checked for specific […] ➡️➡️➡️

Background Web-based depression screenings are commonly used, often providing automated feedback to users. However, there are concerns about potential negative effects, and clear evidence is lacking. Objective The goal of this study was to investigate if automated feedback after screening could lead to: Misdiagnosis Mistreatment Worsening depression Negative emotional responses Increased suicidal thoughts Methods This […] ➡️➡️➡️

Understanding Intertrigo in Obesity Intertrigo is a skin condition that often goes unnoticed in people with obesity. This condition can cause discomfort and skin irritation in areas where skin rubs together. Study Overview This study aimed to find out how common intertrigo is among obese patients and to see how effective a special moisture-wicking fabric […] ➡️➡️➡️

Background The TrialNet Oral Insulin (OI) prevention trial did not show a clear overall benefit when looking at type 1 diabetes as the main goal. However, a delay in the onset of diabetes was observed in a specific group of participants at high risk. Study Overview This analysis focused on a new approach to measure […] ➡️➡️➡️

Background Many studies show that psychotherapy can help people with posttraumatic stress disorder (PTSD). However, not everyone responds the same way to treatment, especially those with complex PTSD (CPTSD). We need better ways to match patients to the treatments that will help them the most. Objective The goal of this study was to create a […] ➡️➡️➡️

Background Since 1999, the standard treatment for locally advanced cervical cancer has been platinum-based chemoradiation (CRT). However, this treatment only improves overall survival by 6% over five years compared to radiotherapy alone. Many patients (30-40%) do not respond completely to CRT, indicating a need for better treatment options. New Approach A new method called Neoadjuvant […] ➡️➡️➡️