The Effect of Vildagliptin vs. Metformin on Liver Fat in Type 2 Diabetes Patients
Study Overview
This study investigated how two medications, vildagliptin and metformin, affect liver fat in patients recently diagnosed with type 2 diabetes (T2D). We used the Hepatic Steatosis Index (HSI) and ultrasound to measure liver health.
Research Details
- Participants: 246 patients with newly diagnosed T2D.
- Groups:
- Group 1: 117 patients received 50 mg of vildagliptin twice daily.
- Group 2: 129 patients received 500 mg of metformin twice daily (can increase to 2000 mg).
- Assessments: Fasting blood sugar, HbA1c, weight, body mass index (BMI), waist and hip measurements, HSI, and ultrasound grading at the start and after 6 months.
Results
Both medications showed significant improvements in blood sugar levels, weight, BMI, and liver fat over 6 months (p < 0.001). However, metformin led to greater weight and BMI loss compared to vildagliptin (p = 0.001 and p = 0.009 respectively). There was no significant difference between the two in liver fat improvement via ultrasound.
Key Findings
- Vildagliptin and metformin are effective for controlling blood sugar in T2D patients.
- Both drugs help reduce liver fat, but metformin is better for weight loss.
- Total cholesterol and LDL cholesterol are important indicators of liver fat levels.
Clinical Value
The findings highlight the effectiveness of both medications in managing T2D and liver health. They also suggest that monitoring cholesterol levels can help predict liver fat issues.
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